Affiliations: Institute for Medical Research, MMA, Belgrade,
Serbia | Clinic of Neurology, MMA, Belgrade, Serbia | Department of Physiology and Biochemistry, Faculty of
Biology, University of Belgrade, Serbia
Note: [] Corresponding author: Lidija Radenovic, Ph.D. Associate
Professor, Department of Physiology and Biochemistry, Faculty of Biology,
University of Belgrade, P.O.B. 52, Studentski trg 16, 11000 Belgrade, Serbia.
Tel.: +381 11 3032356; Fax: +381 11 2638500; 3032356; E-mail:
[email protected]
Abstract: The aim of this study was to define concentration changes of soluble
adhesion molecules (sICAM-1, sVCAM-1 and sE-Selectin) in cerebrospinal fluid
and plasma, as well as, number of peripheral blood leukocytes and the albumin
coefficient in the patients with the acute brain infarction. We also, analyzed
the correlation between the measured levels, the infarct volume and the degree
of neurological and the functional deficit. The study included 50 patients with
the acute cerebral infarction and the control group consisted of 16 patients,
age and sex matched. Obtained results showed significant increase in number of
leukocytes, the albumin coefficient and the level of soluble adhesion molecules
within the first seven days in patients. The highest values of measured
parameters were noted within the third and the fourth day after the insult,
which is the suggested period of maximal intensity of inflammatory reactions.
Significant correlation was found between measured parameters and the infarct
volume, the degree of neurological and the functional deficit. The results
suggest that investigated parameters in CSF and blood represent a dynamic index
of inflammatory events as one of the fundametal mechanisms responsible for
neuron damage during acute phase of brain infarction.
