Oxidative stress is increased in serum from Mexican patients with relapsing-remitting multiple sclerosis

Article type: Research Article

Authors: Ortiz, Genaro Gabriel^; | Macías-Islas, Miguel Ángel | Pacheco-Moisés, Fermín P. | Cruz-Ramos, José A. | Sustersik, Silvia | Barba, Elías Alejandro | Aguayo, Adriana

Affiliations: Laboratorio de Estrés Oxidativo & Patología, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México | División de Ciencias de la Salud, Instituto Tecnológico de Estudios Superiores de Monterrey (ITESM) Campus Guadalajara, Zapopan, Jalisco, México | Departamento de Neurología, Unidad Médica de Alta Especialidad (UMAE)- Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), IMSS, Guadalajara, Jalisco, México | Departamento de Neurosciences, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, México | Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, Jalisco, México | Fundación Mexicana para la Esclerosis Múltiple A.C. Guadalajara, Jalisco, México

Note: [] Corresponding author: Genaro G. Ortiz MD., PhD, Laboratorio Estrés Oxidativo & Patología, CIBO-IMSS. & ITESM, Sierra Mojada 800 C.P. 44340, Guadalajara, Jalisco, México. E-mail: [email protected]

Abstract: Objective: To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis. Methods: Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification. Results: Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress.

Keywords: Multiple sclerosis, oxidative stress, nitric oxide, lipid peroxidation, glutathione peroxidase

DOI: 10.3233/DMA-2009-0602

Journal: Disease Markers, vol. 26, no. 1, pp. 35-39, 2009