Age-dependent decrease in serum transforming growth factor
(TGF)-beta 1 in healthy Japanese individuals; population study of serum
TGF-beta 1 level in Japanese
Affiliations: Division of Health Care Pharmacy, Faculty of Pharmacy,
Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan | Department of Pediatrics, Nagoya Daini Red Cross
Hospital, 2-9 Myoken-cho, Showa-ku, Nagoya 466-8650, Japan | Department of Pediatrics, Komaki City Hospital, 1-20
Jyobushi, Komaki, Aich, 485-8520, Japan
Note: [] Corresponding author: Yoshihiro Okamoto, Division of Immunology
and Microbiology, School of Pharmaceutical Sciences, Chiba Institute of
Science, 3-Shiomicho, Choshi, Chiba 288-0025, Japan. Tel.: +81 479 30 4500;
Fax: +81 479 30 4501; E-mail: [email protected]
Abstract: Transforming growth factor-beta1 (TGF-β1), a multi-functional
cytokine, is involved in regulating a variety of cellular activities and the
serum/plasma TGF-β1 level is altered with various diseases. However, most
published reports have described adult patients, and so we investigated the
clinical significance of serum TGF-β1 level in pediatric patients. The
diagnostic application of the measurement of serum TGF-β1 level depends
critically on the control value, however, there is no information on the
control value of serum TGF-β1 for children. In the present study, we determined the serum TGF-β1 level of
healthy Japanese children as a control value with enzyme-linked immunosorbent
assay (ELISA). The serum TGF-β1 level of children (0–14 years old) was
significantly higher than that of adults (over 15 years old) (p < 0.01).
Thus, it is recommended that when the serum TGF-β1 levels of patients are
evaluated, they should be compared with those of age-matched controls.
