Article type: Research Article
Authors: Pastorello, M.T. | Costa, R.S. | Ravinal, R.C. | Coimbra, M. | dos Reis, M.A | Dantas, M.
Affiliations: Deptment of Pathology, Medical School of
Ribeirão Preto, University of São Paulo, Brazil | Deptment of Physiology, Medical School of
Ribeirão Preto, University of São Paulo, Brazil | Deptment of General Pathology, Medical School of
Triângulo Mineiro, Uberaba, Brazil | Deptment of Clinical Medicine, Medical School of
Ribeirão Preto, University of São Paulo, Brazil
Note: [] Corresponding author: Roberto Silva Costa, MD, PhD, Department
of Pathology, Medical School of Ribeirão Preto, University of São
Paulo, Av. Bandeirantes 3900, RIBEIRÃO PRETO – SP, 14049-900,
Brazil. Tel./Fax: 16 633 1068; E-mail: [email protected]
Abstract: Recent studies have demonstrated that α-Smooth Muscle actin
expression in glomerular and tubulointerstitial compartments of renal tissue
could represent a prognostic marker in several renal diseases. Our objective
was to identify the prognostic value of α-SM actin actin expression on
the evolution of renal damage in Primary IgA nephropathy (Berger's Disease). 43
patients followed up from 1988 to 1999 at the University Hospital, Faculty of
Medicine of Ribeirão Preto, University of São Paulo, Brazil, was
studied. Clinical-laboratory data were obtained from the medical records of the
patients using a protocol containing name, race, gender, origin, profession,
age at clinical presentation of the disease and personal and family history.
The parameters assessed in the approach to IgA nephropathy were serum
creatinine, creatinine clearance, serum albumin, total serum protein, 24 hours
proteinuria, glycaemia, serum sodium, potassium, calcium and phosphorus ions,
analysis of urinary sediment, serum complement profile, blood count, and renal
biopsy. Morphological evaluation was performed by renal biopsy using common
light and immunofluorescence microscopy. Immunohistochemical studies were
performed using a murine monoclonal antibody to α-SM actin. Our data
showed that α-SM actin expression in the glomerular and
tubulointerstitial compartments are not correlated with unfavorable clinical
course of primary IgA nephropathy.
Keywords: Berger's disease, primary IgA nephropathy, glomerulonephritis, hematuria, α-SM actin, prognostic factors, chronic renal progression
Journal: Disease Markers, vol. 21, no. 1, pp. 21-27, 2005
Received 23 February 2005
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Accepted 23 February 2005
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Published: 2005
