Advancement of biomarker discovery and validation through the HUPO plasma proteome project

Article type: Research Article

Authors: Omenn, Gilbert S.

Affiliations: University of Michigan, A510 MSRB I, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0656, USA. Tel.: +1 734 763 7583; Fax: +1 734 647 8148; E-mail: [email protected]

Abstract: The Human Proteome Organization (HUPO) Plasma Proteome Project has mounted a Pilot Phase focussed on key problems essential for standardization of specimen collection, specimen handling, choice of fractionation and analysis technologies, and search engines and databases for protein identifications. This international collaboration will lay the groundwork for many large-scale clinical and epidemiological studies of health and disease.

Keywords: plasma proteome, human proteome organization (HUPO), reference specimens, protein databases/data repository, biomarkers

Journal: Disease Markers, vol. 20, no. 3, pp. 131-134, 2004