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Issue title: Functional Imaging of Early Markers of Disease
Article type: Research Article
Authors: Hielscher, A.H. | Bluestone, A.Y.; | Abdoulaev, G.S. | Klose, A.D. | Lasker, J. | Stewart, M. | Netz, U. | Beuthan, J.
Affiliations: Departments of Biomedical Engineering and Radiology, Columbia University, New York, NY, USA | Departments of Pathology and Physiology and Pharmacology, SUNY – Downstate Medical Center, Brooklyn, NY, USA | Institut für Medizinische Physik und Lasermedizin, Freie Universität Berlin, Berlin, Germany
Note: [] Corresponding author. Departments of Biomedical Engineering and Radiology, Columbia University, ET 351 Mudd Building, MC8904, 500 W. 120 Street, New York, NY 10027-6623, USA. Tel.: +1 212 854 5080; Fax: +1 212 854 8725; E-mail: [email protected]
Abstract: Diffuse optical tomography (DOT) is emerging as a viable new biomedical imaging modality. Using near-infrared (NIR) light, this technique probes absorption as well as scattering properties of biological tissues. First commercial instruments are now available that allow users to obtain cross-sectional and volumetric views of various body parts. Currently, the main applications are brain, breast, limb, joint, and fluorescence/bioluminescence imaging. Although the spatial resolution is limited when compared with other imaging modalities, such as magnetic resonance imaging (MRI) or X-ray computerized tomography (CT), DOT provides access to a variety of physiological parameters that otherwise are not accessible, including sub-second imaging of hemodynamics and other fast-changing processes. Furthermore, DOT can be realized in compact, portable instrumentation that allows for bedside monitoring at relatively low cost. In this paper, we present an overview of current state-of-the -art technology, including hardware and image-reconstruction algorithms, and focus on applications in brain and joint imaging. In addition, we present recent results of work on optical tomographic imaging in small animals.
Keywords: tomography, instrumentation, image reconstruction, scattering media, brain and joint imaging
Journal: Disease Markers, vol. 18, no. 5-6, pp. 313-337, 2002
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