Association of Epstein-Barr virus with human mammary carcinoma. Pros and cons

Article type: Research Article

Authors: Touitou, Robert | Bonnet-Duquenoy, Mathide | Joab, Irène

Affiliations: INSERM, Hôpital Saint Louis, 27 rue Juliette Dodu, Paris, France | Ludwig Institute for Cancer Research, London, UK

Note: [] Tel.: +33 1 42 49 92 68; Fax: +33 1 42 49 48 38; E-mail: [email protected]

Abstract: The Epstein-Barr virus (EBV) is associated with the development of different malignancies. In the last few years, EBV has been detected in a subset of breast tumors. The EBV genome was detected by PCR and Southern-blot analysis and identification of the infected cells was determined using different {\it in situ} methods. EBV has detected more frequently in steroid hormone receptors negative tumors, in high histological SBR grade tumors and furthermore, the EBV genome was also observed in metastatic lymph nodes, along with EBV detection in the primary tumor. Opposing results are discussed.

Journal: Disease Markers, vol. 17, no. 3, pp. 163-165, 2001