HLA-Association in patients with intolerance to mercury and other metals in dental materials

Article type: Research Article

Authors: Proch\'azkov\'a, J. | B\'artov\'a, J. | Iva\v{s}kov\'a, E. | Kupkov\'a, L. | \v{S}terzl, I. | Stejskal, V.D.M.

Affiliations: Institute of Dental Research, Vinohradsk\'a 48, 120 60 Prague 2, Czech Republic | IKEM, National HLA Centre, V\'{\i}de\v{n}sk\'a 800, 140 00 Prague 4, Czech Republic | Institute of Endocrinology, N\'arodn\'{\i} 8, 116 94 Prague 1, Czech Republic | Department of Clinical Chemistry, Danderyds Hospital and Karolinska Institute, Stockholm, Sweden

Note: [] Institute of Dental Research, General Faculty Hospital of Charles University Prague, Vinohradsk\'a 48, 120 60 Prague 2, Czech Republic. Tel.: +4202 24256718; Fax: +4202 24247034; E-mail: [email protected]

Abstract: A group of selected 25 patients with serious intolerance to heavy metals used for dental restoration were examined for HLA antigens. A significant increase for HLA -- B37, B47 and DR4 was found. The value of the relative risk is not significant after correction for the number of antigens tested and therefore further studies of more patients are needed.

Keywords: HLA antigens, metal intolerance, dental materials

Journal: Disease Markers, vol. 16, no. 3-4, pp. 135-138, 2000