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Article type: Research Article
Authors: Rendu, Francine | Viret, Jacques | Daveloose, Denis | Testylier, Guy | Levy-Toledano, Sylviane | Leterrier, François
Affiliations: Division de Biophysique du CRSSA, F92141 CLAMART and Unité INSERM U150, Hôpital Lariboisière, F75010 PARIS
Note: [] Accepted by: Editor J.F. Stoltz
Abstract: Using the spin-label method, we have compared the physical state of the human platelet membrane before and after thrombin-induced aggregation. In its resting state this membrane is rigid and highly organized. After aggregation, its ordering decreases. This phenomenon is dose dependent and reaches its maximum with about 0.5 U/ml of thrombin for 3.109 platelets per ml. Preliminary results obtained on genetic diseases (Glanzman thrombasthenia and Gray platelets syndrome) indicate that this change is independent from the aggregation phenomenon itself. In thromboembolic states (thrombocytemia, diabetes) the membrane molecular structure of platelets at rest seems to be similar to that of activated normal platelets.
Keywords: platelet membrane, spin-labeling, order, microviscosity
DOI: 10.3233/CH-1985-5517
Journal: Clinical Hemorheology and Microcirculation, vol. 5, no. 5, pp. 523-530, 1985
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