Affiliations: [a] Endocrinology and Metabolism Research Centre, University of Tehran/Medical Sciences, Tehran, Iran | [b] Department of Pathology, Shariati hospital, University of Tehran/Medical Sciences, Tehran, Iran | [c] Immunogenetics Lab, Department of Immunology, University of Tehran/Medical Sciences, Tehran, Iran | [d] Hematology-Oncology and Stem Cell Research Center, University of Tehran/Medical Sciences, Tehran, Iran | [e] Otolaryngology and Head & Neck Surgery Research Centre, University of Tehran/Medical Sciences, Tehran, Iran
Correspondence:
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Corresponding author: Mahsa M. Amoli, MD, PhD., EMRC, Dr Shariati Hospital, North Karegar St., Tehran 14114, Iran. Tel.: +98 21 88026902 3; Fax: + 98 21 88029399; E-mail: [email protected].
Abstract: Objective:Papillary thyroid carcinoma (PTC) is the most frequent types of thyroid malignancies. Several genes may be involved in susceptibility of thyroid cancer including Human Leukocyte Antigens (HLA). The association of thyroid carcinoma with HLA alleles has been previously studied in other populations and certain HLA alleles were shown to be either predisposing or protective. The aim of this study was to determine the association between HLA-C allele frequencies and papillary thyroid carcinoma in an Iranian population. Design:HLA-Cw allele frequencies were determined in patients with papillary thyroid carcinoma (N = 54) and non-related healthy controls (N = 91) using PCR-SSP. Main Outcome:We found that HLACw*4 and HLACw*15 allele frequencies were significantly higher in our patients compared to the controls [P=10−4, OR; 12.5, 95% CI 2.6–116.9) and [P=10−4, OR; 24.7, 95% CI (3.6–1058) respectively]. Coclusions:Our results revealed certain HLA-C alleles are predisposing factors in papillary thyroid carcinoma in Iranian population. This confirms the previous findings for association between HLA-C alleles and differentiated carcinomas in other populations.
