¹H magnetic resonance spectroscopy of prostate cancer: Biomarkers for tumor characterization

Issue title: Recent Advances in Imaging the Prostate

Guest editors: Ernest J. Feleppa

Article type: Research Article

Authors: Zakian, Kristen L.^{a; b; *} | Shukla-Dave, Amita^{a; b} | Ackerstaff, Ellen^a | Hricak, Hedvig^b | Koutcher, Jason A.^{a; b; c}

Affiliations: [a] Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, NY, USA | [b] Department of Radiology, Memorial Sloan-Kettering Cancer Center, NY, USA | [c] Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY, USA | Lizzi Center for Biomedical Engineering, Riverside Research Institute, New York, NY, USA

Correspondence: [*] Corresponding author: Kristen L. Zakian, Ph.D., Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA. Tel.: +1 212 639 8595; Fax: +1 212 717 3676; E-mail: [email protected].

Abstract: Proton Magnetic Resonance Spectroscopic Imaging (MRSI) permits a non-invasive assessment of metabolites in the prostate gland. This article reviews the assessment of choline-containing compounds, citrate, and polyamines as markers for prostate tumor detection and aggressiveness.

Keywords: Magnetic resonance, spectroscopy, proton, prostate cancer, choline, detection, Gleason score

DOI: 10.3233/CBM-2008-44-508

Journal: Cancer Biomarkers, vol. 4, no. 4-5, pp. 263-276, 2008