Affiliations: [a] Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA | [b] Department of Obstetrics, Gynecology and Women's Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, USA | [c] Biostatistics and Bioinformatics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA | [d] Department of Surgery, University of Minnesota School of Medicine, Minneapolis, MN, USA
Correspondence:
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Corresponding author: Emil Lou, Division of Hematology, Oncology and Transplantation, University of Minnesota, Mayo Mail Code 480, 420 Delaware Street SE, Minneapolis, MN 55455, USA. Tel.: +1 612 624 5994; Fax: +1 612 625 6919; E-mail:[email protected]
Abstract: BACKGROUND: Appendiceal cancer is a rare malignancy. The optimal
pathologic classification and prognostic factors for survival and treatment
strategies remain poorly understood. OBJECTIVE: The aim of this retrospective cohort study was to
determine prognostic factors, including markers of systemic inflammation,
for survival in a cohort of patients with advanced appendiceal
adenocarcinomas. METHODS: The study included patients with advanced appendiceal
carcinoma that were treated between January 2006 and June 2012. The
associations between age, gender, histopathologic subtype of appendiceal
malignancy and treatment with heated intraperitoneal chemotherapy (HIPEC)
and overall survival (OS) were assessed. The relationship between various
markers of inflammation (platelet-to-lymphocyte ratio,
neutrophil-to-lymphocyte ratio) and OS was also evaluated. RESULTS: A total of 49 patients met eligibility criteria. Female
gender and low-grade adenocarcinoma were associated with increased OS. These
data suggest that the use of HIPEC treatment may also be associated with
improved OS, but the difference was not statistically significant (HR = 0.37
[0.12-1.18], p = 0.09). We found no evidence of an association between
markers of inflammation at diagnosis and OS. CONCLUSIONS: Histopathologic subtype and gender are associated with
OS in patients with advanced appendiceal carcinoma. Baseline platelet
levels, NLR, and PLR do not appear to be predictive of OS in this setting.
Keywords: Appendiceal cancer, HIPEC, prognostic factors, platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio
