Affiliations: [a] Department of Periodontics {&} Oral Medicine, School of Stomatology, Capital Medical University, Beijing, China | [b] Department of Orthodontics, Faculty of Dentistry, Hong Kong University, HK, China | [c] Department of Maxillofacial Surgery, School of Stomatology, Peking University, Beijing, China
Correspondence:
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Corresponding author: Shu-Xia Li, Department of Periodontics {&} Oral Medicine, School of Stomatology, Capital Medical University, Beijing 100050, China. Tel.: +86 10 57099246. Fax: +86 10 57099220; E-mail:[email protected]
Abstract: INTRODUCTION: The aim of this study was to detect the survivin,
carcinoembryonic antigen (CEA) and ErbB2 in the saliva, serum and local
tumor-exfoliated cells of oral squamous cell carcinoma (OSCC) patients, for
providing reliable tumor markers for the early detection of oral malignant cancer. MATERIALS AND METHODS: The saliva, serum, and local
tumor-exfoliated cell samples of 26 OSCC patients without chemotherapy and
10 non-cancer patients were collected in Department of Oral and
Maxillofacial Surgery, School of Stomatology, Peking University. The
contents of survivin, CEA and ErbB2 using were detected usingenzyme-linked immunosorbent assay. RESULTS: The survivin and CEA levels in saliva and local
tumor-exfoliated cells of OSCC patients were significantly higher than those
in the non-cancer patients (P < 0.05), but there was no significant difference
in the content of the above factors in the serum sample between two groups.
There was no significant difference in the ErbB2 content in the saliva,
serum or local tumor-exfoliated cells between two groups. CONCLUSION: Survivin and CEA levels are significantly increased in
the saliva and local tumor-exfoliated cells in OSCC patients, and they can
be used as reliable markers for the early detection of oral malignant
cancer.
