Affiliations: Department of Brothers Microsurgery, Liaoyang Central Hospital, Liaoyang, Liaoning, China
Correspondence:
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Corresponding author: Zihua Li, 148 Zhonghua Street, Department of Brothers Microsurgery, Liaoyang Central Hospital, Liaoning 111000, China. E-mail:[email protected]
Abstract: OBJECTIVE: To evaluate the expression of PARP1 in chordoma and
analyzed its association with clinical factors and patients' prognosis. METHODS: The expression of Poly (ADP-ribose) polymerase 1 (PARP1)
in chordoma specimens from 74 chordoma patients (50 primary and 24 recurrent
tumors of 50 patients)and 20 distant normal tissue specimens was measured by
immunohistochemical staining. The association of PARP1with the clinical
factors and patients' prognosis was also analyzed. RESULTS: Of all the chordoma samples, 78% showed high expression
of PARP1, whereas, only 10% of distant normal tissues expressed a high
level of PARP1 (p< 0.01). Chi-square analysis revealed that high expression
of PARP1 was significantly correlated with tumor recurrence (p< 0.01) and
invasion into surrounding muscle (p< 0.01), while the data did not indicate
any association with patients' gender, age, tumor location and size
(p> 0.05). Kaplan-Meier survival curve and log-rank test showed that
continuous disease free survival time (CDFS) was significantly shorter in
the PARP1-positive group than in the PARP1-negative group (P= 0.019). CONCLUSION: High expression of PARP1 is significantly associated
with chordoma invasion and recurrence. PARP1 may become a potential
biomarker for chordoma in predicting its recurrence and patients' prognosis.
