Affiliations: [a] Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China | [b] Shanghai Colorectal Cancer Research Center, Shanghai, China
Correspondence:
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Corresponding author: Jihong Fu, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Rd, Shanghai, China. Fax: +86 21 25077855; E-mail:[email protected]
Abstract: BACKGROUND: Our previous study found ANLN was over-expressed in
colorectal cancer(CRC), however the role of ANLN in CRC remained unknown. OBJECTIVE: To investigate the relationship of ANLN expression in
CRC with clinical features and to determinate the prognostic significance of
ANLN expression in CRC. METHODS: The ANLN expression in CRC tissue and adjacent normal
colorectal mucosa were measured, the relationship between ANLN expression
and clinical features as well as overall survival were analyzed. RESULTS: ANLN was overexpressed in CRC. ANLN expression
was associated with tumor invasion and enlarged tumor size. Furthermore,
Kaplan-Meier survival analysis revealed that higher expression of ANLN was
associated with poorer overall survival. Multi-variate analysis suggested
that higher expression of ANLN, preoperative CEA level and distant
metastasis were independent prognostic factor in patients with CRC CONCLUSIONS: ANLN expression is elevated in CRC and has a strong
potential to act as a biomarker for the prognosis of CRC.
