Affiliations: [a] Department of Surgery Medicine, Division of Thoracic Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China | [b] Department of Hospital Infection Management, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China | [c] Department of Medical, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China | [d] Hepatobiliary and Pancreatic Surgery, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China | [e] Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China
Correspondence:
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Corresponding author: Chunhua Song, Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China. E-mail:[email protected]
Abstract:
BACKGROUND: DNA methyltransferase 3B (DNMT3B) has been discovered
to play an important role in tumorigenesis. However, the association between
DNMT3B-579G>T and the cancer risk has not been demonstrated. OBJECTIVE: The aim of this study is to provide a precise
quantification for the association between DNMT3B-579G>T and the cancer
susceptibility. METHODS: We performed a systematic literature review and assessed
the methodological quality of included case-control designed studies based
on Newcastle-Ottawa Scale (NOS). Pooled odds ratios (ORs) and corresponding
95% confidence intervals (95%CIs) were calculated to assess the
strengths of the association. RESULTS: We identified 18 studies for pooled analyses. Overall, the
results demonstrated that the DNMT3B-579G>T polymorphism was significantly
associated with a subtly decreased cancer risk (GT vs TT: OR = 0.78, 95%CI:
0.70-0.87, P< 0.01; GT + GG vs TT: OR = 0.81, 95%CI: 0.68-0.97, P= 0.02),
especially in the Asian population and in colorectal cancer subgroup. In
addition, when stratified for source of controls, the results of
population-based subgroup showed the GT genotype might have a significantly
decreased cancer risk, but not hospital-based subgroups. CONCLUSIONS: DNMT3B-579G>T polymorphism might contribute to the
susceptibility of cancers especially in the Asian population and for
colorectal cancer.
