Affiliations: [a] Department of gastrointestinal surgery, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China | [b] Ethics Committee, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China | [c] Department of Gastroenterology, 2nd Affiliated Hospital of Jilin University, Changchun, Jilin, China
Correspondence:
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Corresponding author: Liwei Duan, Department of Internal Gastroenterology, 2nd Affiliated Hospital of Jilin University, Changchun 130041, Jilin, China. Tel.: +1 86 431 88796978; E-mail: spd52291@163
Abstract: microRNAs (miRNAs) are small non-coding RNAs that play important role in a
variety of biological processes, and aberrant expression of miRNA is always
associated with tumor progression and invasion. However, the role of miR-206
in colorectal cancer (CRC) is still unclear. In this study, the expression
of miR-206 in CRC tissue was compared to paired normal adjacent tissue, and
results indicate that miRNA-206 levels are significantly lower in CRC tissue
compared to control tissue. Kaplan-Meier analysis showed that patients with
low miR-206 expression had significantly poorer overall survival. In
addition, we found that over-expression of miR-206 can inhibit CRC cell
migration and invasion. In conclusion, our results suggest that miR-206
functions as a tumor suppressor by inhibiting CRC migration and invasion.
These findings suggest that miR-206 may be useful as a new potential
therapeutic target for CRC.
Keywords: miR-206, colorectal cancer, prognosis, cell growth and invasion
