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Subtitle:
Article type: Research Article
Authors: Kilic, Leylaa; * | Yildiz, Ibrahimb | Sen, Fatma Karagozb | Erdem, Mustafa Gencoc | Serilmez, Muratd | Keskin, Serkanb | Ciftci, Rumeysab | Karabulut, Senemb | Ordu, Cetine | Duranyildiz, Deryad | Tas, Farukb
Affiliations: [a] Medical Oncology Department, Firat University Hospital, Elazig, Turkey | [b] Medical Oncology Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey | [c] Agri Hamur State Hospital, Internal Medicine Clinic, Hamur, Agri, Turkey | [d] Biochemistry Department, Institute of Oncology, Istanbul University, Capa, Istanbul, Turkey | [e] Medical Oncology Department, Bedii Gorbon Oncology Center, Avrupa Florence Nightingale Hospital, Sisli, Istanbul, Turkey
Correspondence: [*] Corresponding author: Leyla Kilic, Department of Medical Oncology, Firat University Hospital, Zip Code: 23040, Elazig, Turkey. Tel.: +90 505 455 97 60, +90 424 233 35 55; E-mail: [email protected]
Abstract: BACKGROUND: The aim of this study is to evaluate the correlation of coagulation tests with various clinicopathological variables and tumor markers among colorectal cancer (CRC) patients. MATERIALS AND METHODS: Ninety-four CRC patients were included for evaluation of clinicopathological factors, coagulation assays and tumor marker levels. RESULTS: Metastatic disease was related with elevated INR (p= 0.03). Stage III patients had higher D-dimer values compared with stage II patients (p= 0.03). Correlation of tumor markers indicated a tendency towards elevated D-dimer levels for CEA values higher than median (p= 0.01). High CA 19-9 levels were also associated with higher INR (p= 0.007). Elderly age, distant metastasis, high CEA, CA-19-9 and LDH levels were associated with poorer overall-survival. CEA level was the only independent prognostic factor in multivariate analysis. CONCLUSIONS: Coagulation assays can be utilized as predictors of disease extent in CRC. Elevated D-dimer and INR values may indicate higher disease stage. Correlation of D-dimer levels with CEA supports their value for assessing tumor burden.
Keywords: Tumor marker, coagulation, colon cancer, D-dimer, CEA, CA 19-9
DOI: 10.3233/CBM-150477
Journal: Cancer Biomarkers, vol. 15, no. 4, pp. 405-411, 2015
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