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Article type: Research Article
Authors: Zhu, Peia; b; c; 1 | Qian, Tingtinga; b; c; 1 | Si, Chaozengd; 1 | Liu, Yane; f | Cui, Longzhene; f | Huang, Wenhuia; b; c | Fu, Lina; b; c; e; f; * | Deng, Congg; * | Zeng, Tianshenga; b; c; *
Affiliations: [a] Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China | [b] Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China | [c] Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China | [d] Information Center, China-Japan Friendship Hospital, Beijing, China | [e] Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, Henan, China | [f] Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, Henan, China | [g] Department of Clinical Laboratory, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
Correspondence: [*] Corresponding authors: Lin Fu, Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China. E-mail: [email protected]. Cong Deng, Department of Clinical Laboratory, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China. E-mail: [email protected]. Tiansheng Zeng, Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China. E-mail: [email protected].
Note: [1] These authors contributed equally to this work.
Abstract: BACKGROUND:CPNEs are significant biomarkers which can affect the progression and prognosis of various tumor diseases. However, the prognosis role of CPNEs in multiple myeloma (MM) is still unclear. OBJECTIVES: To investigate the prognosis role of CPNEs in MM. METHODS: Seven hundred and thirty-five samples from two independent data sets were involved to analyze the clinical and molecular characteristics, and prognosis role of the expression of CPNE1-9 in MM. RESULTS: MM patients with higher expressions of CPNE5 and CPNE9 had longer event-free survival (EFS) and overall survival (OS) compared with CPNE5low and CPNE9low expression groups (EFS: P= 0.0054, 0.0065; OS: P= 0.015, 0.016, respectively). Multivariate regression analysis showed that CPNE5 was an independent favorable predictor for EFS and OS (EFS: P= 0.005; OS: P= 0.006), and CPNE9 was an independent positive indicator for EFS (P= 0.002). Moreover, the survival probability and the cumulative event of EFS and OS in CPNE5highCPNE9high group were significantly longer than other groups. CONCLUSIONS: High expressions of CPNE5 and CPNE9 might be used as positive indicators for MM, and their combination was a better predictor for the survival of MM patients.
Keywords: Multiple myeloma, CPNE5, CPNE9, prognosis
DOI: 10.3233/CBM-203108
Journal: Cancer Biomarkers, vol. 31, no. 1, pp. 77-85, 2021
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