FOXO1 overexpression is correlated with poor prognosis in epithelial ovarian cancer

Article type: Research Article

Authors: Liu, Longyang^{a; b; 1} | Yi, Juanjuan^{c; 1} | Yuan, Jianhuan^{d; 1} | Yao, Tingting^e | Lin, Zhongqiu^e | Ning, Yingxia^{f; g; *} | Zeng, Zhaoyang^{h; *}

Affiliations: [a] Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China | [b] Southern Medical University, Guangzhou, Guangdong, China | [c] Department of Dermatovenereology, Foshan Women and Children Hospital, Foshan, Guangdong, China | [d] Department of Gynecology, The First People’s Hospital of Huizhou City, Huizhou, Guangdong, China | [e] Department of Gynecology Oncology, The Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China | [f] Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China | [g] Guangzhou Medical University, Guangzhou, Guangdong, China | [h] Department of Gynecology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China

Correspondence: [*] Corresponding authors: Yingxia Ning, Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. E-mail: [email protected]; Zhaoyang Zeng, Department of Gynecology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 13 Shiliugang ST, Guangzhou, Guangdong, 510315, China. E-mail: [email protected].

Note: [1] Co-first author.

Abstract: OBJECTIVE: To investigate FOXO1 expression in epithelial ovarian cancer (EOC), and to explore its correlation with clinicopathological parameters and prognosis of EOC. METHODS: Two hundred and sixteen cases of paraffin-embedded EOC and 41 paratumor tissues from 2009 to 2017 that had been pathologically confirmed at the memorial hospital of Sun Yat-sen University were included in this study, and the expression of FOXO1 was performed by immunohistochemistry using a polyclonal antibody specific for FOXO1. RESULTS: FOXO1 protein expression is associated with Recurrence free and overall survival in EOC patients; In addition, FOXO1 expression is associated with age, FIGO stage, intraperitoneal metastasis, intestinal metastasis, vital status, intraperitoneal recurrence and differentiation grade; Moreover, in a multivariate model FOXO1 overexpression was an independent predictor of poor survival in EOC. CONCLUSION: FOXO1 may play a candidate oncogenic role in EOC, and FOXO1 is a useful independent prognostic marker in EOC, and it may provide a candidate target therapy in future.

Keywords: FOXO1, epithelial ovarian cancer, prognosis

DOI: 10.3233/CBM-182119

Journal: Cancer Biomarkers, vol. 28, no. 1, pp. 1-8, 2020