Expression and clinical significance of transcription factor 4 (TCF4) in epithelial ovarian cancer

Article type: Research Article

Authors: Liu, Longyang^{a; 1} | Zeng, Zhaoyang^{a; 1} | Yi, Juanjuan^{b; 1} | Zuo, Liu^c | Lv, Jin^c | Yuan, Jianhuan^d | Lin, Zhongqiu^e | Luo, Rongcheng^{c; *} | Feng, Xin^{f; *}

Affiliations: [a] Department of Gynecology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510315, China | [b] Department of Dermatovenereology, Foshan Maternal and Child Health Hospital, Foshan, Guangdong 528000, China | [c] Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510315, China | [d] Department of Gynecology, The Fisrt People’s Hospital of Huizhou City, Huizhou, Guangdong 516000, China | [e] Department of Gynecology Oncology, The Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510000, China | [f] Department of Gynecology Oncology, The Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China

Correspondence: [*] Corresponding authors: Rongcheng Luo, Cancer Center, Southern Medical University, Guangzhou, Guangdong 510315, China. Xin Feng. Department of Gynecology Oncology, The Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China. E-mail: [email protected].

Note: [1] Co-first authors: Longyang Liu, Zhaoyang Zeng, Juanjuan Yi.

Abstract: OBJECTIVES: To investigate TCF4 expression in epithelial ovarian cancer, and to explore its correlation with clinicopathological parameters and clinical prognosis of epithelial ovarian cancer. METHODS: From 2009 to 2017, 188 cases of paraffin-embedded epithelial ovarian cancer tissues and 41 paratumor ovarian tissues which had been confirmed at the memorial hospital of Sun Yat-sen University were collected in this study, and the expression of TCF4 was performed by immunohistochemistry using a polyclonal antibody specific for TCF4. RESULTS: The expression of TCF4 protein was associated with disease progression free survival and overall survival in epithelial ovarian cancer patients; and TCF4 overexpression was associated with age, FIGO stage, lymph node metastasis, intraperitoneal metastasis, intestinal metastasis, vital status, intraperitoneal recurrence, and serum CA153. Moreover, in a multivariate Cox regression analysis TCF4 overexpression was an indeed independent prognostic factor in epithelial ovarian cancer. CONCLUSIONS: TCF4 may play an oncogenic role in epithelial ovarian cancer, and TCF4 is a useful independent prognostic biomarker of epithelial ovarian cancer, and it may provide a candidate target therapy treatment in future.

Keywords: TCF4, ovarian cancer, expression, clinical significance

DOI: 10.3233/CBM-181849

Journal: Cancer Biomarkers, vol. 24, no. 2, pp. 213-221, 2019