Affiliations: [a] School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India | [b] School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India | [c] Department of Research and Development, Lovely Professional University, Phagwara, Punjab 144411, India
Correspondence:
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Corresponding author: Jeena Gupta, Department of Biochemistry, School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar, Delhi G.T. Road, Phagwara, Punjab 144411, India. Tel.: +91 1824 404404; Fax: +91 1824 506111; E-mail: [email protected].
Note: [1] These authors share the first authorship.
Abstract: Cancer, a deadly disease is characterized by abnormal cell growth with the potential to invade to other parts of the body. Most cancers start due to changes at gene level that happen over a person’s lifetime when DNA repair system becomes faulty. CCDC6, one of the players in DNA repair system acts as a tumor suppressor gene. It was originally identified in chimeric genes caused by chromosomal translocation involving RET proto-oncogene in some thyroid tumors. Different fusion chimers with different proto-oncogenes like RET are known for CCDC6 which hampered its function. Further, CCDC6 is recognized as a pro-apoptotic phosphoprotein, which is an ATM substrate responsive to genotoxic stress. In this article, we reviewed the published literature to characterize CCDC6 fusions with proto-oncogenes and the role of natural phytochemicals which can potentially alter CCDC6 activity and thus can prove beneficial for cancer patients.
Keywords: CCDC6, cancer, chimeric protein, DNA repair, proto-oncogenes
