Prognostic significance of peripheral blood absolute monocyte count and lymphocyte to monocyte ratio in anaplastic large cell lymphoma

Article type: Research Article

Authors: Jia, Tao^{a; b; c; d; 1} | Zhang, Run^{a; b; c; 1} | Zhu, Hua-Yuan^{a; b; c} | Liang, Jin-Hua^{a; b; c} | Wang, Li^{a; b; c} | Wu, Wei^{a; b; c} | Cao, Lei^{a; b; c} | Li, Jian-Yong^{a; b; c} | Xu, Wei^{a; b; c; *}

Affiliations: [a] Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu, China | [b] Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, Jiangsu, China | [c] Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing 210029, Jiangsu, China | [d] Department of Hematology, The First People’s Hospital of Lianyungang City, Lianyungang 222002, Jiangsu, China

Correspondence: [*] Corresponding author: Wei Xu, Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu, China. Tel.: +86 25 83781120; Fax: +86 25 83781120; E-mail: [email protected].

Note: [1] Tao Jia and Run Zhang contributed equally to this work.

Abstract: BACKGROUND: Peripheral blood absolute monocyte count (AMC) and lymphocyte to monocyte ratio (LMR) have strong prognostic value in various forms of lymphomas. It was found that higher AMC and lower LMR were associated with poor prognosis in B cell lymphoma. However, their prognostic significance in systemic anaplastic large cell lymphoma (sALCL) remained to be determined. OBJECTIVE: This study was aimed at investigating the prognostic significance of AMC and LMR in sALCL. METHODS: A total of 29 newly diagnosed patients with sALCL were retrospectively included in study, prognostic significance of AMC, LMR, performance status (PS), international prognostic index (IPI), prognostic index for T-cell lymphomas (PIT) and other indicators were analyzed. RESULTS: Univariate analysis showed high AMC, LMR < 2.5, PS ⩾ 2, extranodal involvement, no response to treatment and B symptoms predicted inferior PFS; LMR < 2.5, no response to treatment, elevated LDH, IPI ⩾ 3, PIT ⩾ 2 and PS ⩾ 2 predicted inferior OS. High AMC, PS ⩾ 2 were independent prognostic factors for PFS; PS ⩾ 2, no response to treatment and elevated LDH were independent prognostic factors for OS. CONCLUSIONS: AMC was an independent prognostic factor for PFS in sALCL, and LMR < 2.5 also indicated poor prognosis.

Keywords: Anaplastic large cell lymphoma, absolute monocyte count, absolute lymphocyte count, lymphocyte to monocyte ratio, prognosis

DOI: 10.3233/CBM-181505

Journal: Cancer Biomarkers, vol. 22, no. 4, pp. 807-813, 2018