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Article type: Research Article
Authors: Yan, Jinhuaa | Wu, Guohea | Chen, Jianlana | Xiong, Lifanga | Chen, Guoanb; 1; * | Li, Pinga; 1; *
Affiliations: [a] Department of Hematology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China | [b] Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
Correspondence: [*] Corresponding authors: Guoan Chen, Department of Hematology, The First Affiliated Hospital of Nanchang University, No. 17, Yongwai Centre Street, East Lake District, Nanchang City, Jiangxi 330006, China. E-mail: [email protected],DepartmentofHematology,TheThirdAffiliatedHospitalofNanchangUniversity,No.128,XiangshanNorthRoad,EastLakeDistrict,NanchangCity,Jiangxi330008,China.Tel./Fax:+86079188862270;E-mail:[email protected].
Note: [1] These authors contributed equally.
Abstract: BACKGROUND:Circulating microRNAs (miRNAs) play an essential role in the development and progression of acute myeloid leukemia (AML). However, the clinical value of serum miR-217 in AML remained poorly known. OBJECTIVE: This study aimed to explore the clinical significance of serum miR-217 in AML. METHODS:Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was performed to detect miR-217 levels in the blood samples obtained from 89 AML patients and 60 healthy controls. RESULTS: The results showed that miR-217 expression was significantly decreased in AML patients compared to controls. Likewise, serum miR-217 levels were greatly downregulated in the AML patients with poor risk cytogenetic. ROC analysis demonstrated that serum miR-217 could effectively differentiate AML patients from normal controls. Also, miR-217 expression was markedly increased in patients achieving complete remission after their treatment. In addition, low miR-217 expression was associated with aggressive clinical features. Moreover, Kaplan-Meier analysis showed that AML patients with low miR-217 expression tended to have shorter overall survival and disease free survival. In the multivariate analysis stratified for prognostic parameters, miR-217 was proved to be an independent prognostic indicator. CONCLUSIONS:Collectively, miR-217 was identified as an independent marker for the diagnosis and prognosis of AML.
Keywords: Acute myeloid leukemia, prognostic biomarker, miR-217, serum
DOI: 10.3233/CBM-170936
Journal: Cancer Biomarkers, vol. 22, no. 1, pp. 73-78, 2018
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