Affiliations: [a] Department of Oral Pathology, Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China | [b] College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, Heilongjiang, China
Correspondence:
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Corresponding author: Eryang Zhao, Department of Oral Pathology, Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China. Tel.: +86 451 85553807; E-mail:[email protected]
Abstract: PURPOSE: The objective of this study was to
explore the prognostic value of in situ memory T cells and patterns of
invasion (POI) in early stage oral squamous cell carcinoma (OSCC). METHODS: One hundred fifty-seven patients with early stage (cT1T2N0) OSCC
were identified from a pre-existing database of patients with oral cancer
and were classified by POI according to hematoxylin-eosin staining. We
examined the impact of the immunohistochemical expression of CD45RO in OSCC.
Overall survival (OS) curves were calculated using the Kaplan-Meier method. RESULTS: Margin status was significantly associated with local recurrence in
early stage OSCC (p= 0.000), and depth of invasion was also associated with
regional recurrence (2 mm: p= 0.034; 4 mm: p= 0.015). The expression of CD45RO
(p= 0.021) and POI (p= 0.027) individually was associated with OS, and
patients in the group with combination score tended to have worse OS (p=
0.012). CONCLUSION: Combined evaluation of POI and CD45RO might prove to be a useful
indicator for high-risk patients with occult metastases from early stage
OSCC.
Keywords: CD45RO, patterns of invasion, oral squmaous cell cacinoma, early stage
