PPARGC1A and ADIPOQ polymorphisms are associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity

Article type: Research Article

Authors: Canto, Patricia^{a; b; *} | Granados, Jesús Benítez^a | Feria-Bernal, Guillermo^c | Coral-Vázquez, Ramón Mauricio^{d; e} | García-García, Eduardo^b | Tejeda, María Elena^a | Tapia, André^a | Rojano-Mejía, David^f | Méndez, Juan Pablo^{a; b; *}

Affiliations: [a] Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México, México, México | [b] Clínica de Obesidad, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, México, México | [c] Departamento de Urología, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, México, México | [d] Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, México | [e] Subdirección de Enseñanza e Investigación, Centro Médico Nacional “20 de Noviembre”, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, México, México | [f] Unidad de Medicina Física y Rehabilitación Centro, UMAE, Hospital de Traumatología y Ortopedia “Lomas Verdes”, Instituto Mexicano del Seguro Social, México, México

Correspondence: [*] Corresponding authors: Patricia Canto, Unidad de Investigación en Obesidad, Facultad de Medicina, Universidad Nacional Autónoma de México. México, D.F., México. Tel.: +5255 54870900 extension 5068; E-mail: [email protected]éndezUnidaddeInvestigaciónenObesidad,FacultaddeMedicina,UniversidadNacionalAutónomadeMéxico.México,D.F.,México.Tel.:+525554870900extension5068:E-mail:[email protected].

Abstract: BACKGROUND: Obesity constitutes a risk factor for the development of aggressive forms of prostate cancer. It has been proposed, that prostate cancer has a genetic predisposition and that PPARGC1A and ADIPOQ polymorphisms play a role in the development of this condition. OBJECTIVE: To analyse the association of two PPARGC1A and ADIPOQ polymorphisms as well as their haplotypes, with the development of aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity. SUBJECTS AND METHODS: Two hundred fifty seven men with prostate cancer of Mexican-Mestizo origin were included. Body mass index (BMI) was determined and the degree of prostate cancer aggressiveness by the D’Amico classification. DNA was obtained. Rs7665116 and rs2970870 of PPARGC1A, and rs266729 and rs1501299 of ADIPOQ were studied by real-time PCR allelic discrimination. Pairwise linkage disequilibrium, between single nucleotide polymorphisms was calculated and haplotype analysis was performed. RESULTS: A higher-risk (D’Amico classification) was observed in 21.8% of patients. An association of cancer aggressiveness with rs2970870 of PPARGC1A, and rs501299 of ADIPOQ, as well as with one haplotype of ADIPOQ was documented. CONCLUSIONS: This is the first study regarding the relationship of PPARGC1A and ADIPOQ polymorphisms, and the aggressiveness of prostate cancer in men with overweight or obesity.

Keywords: Aggressive prostate cancer, overweight, obesity, polymorphisms, PPARGC1A, ADIPOQ

DOI: 10.3233/CBM-160467

Journal: Cancer Biomarkers, vol. 19, no. 3, pp. 297-303, 2017