Affiliations: [a] Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China | [b] Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shangdong, China | [c] Department of Reproductive Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Correspondence:
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Corresponding author: Wanpeng Liu, Department of Reproductive Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, China. E-mail:[email protected]
Note: [1] These two authors contributed to this work equally.
Abstract: BACKGROUND: Histone deacetylase 6 (HDAC6) is correlated with
poor/better survival from cancers. This study was designed to investigate the
correlation between HDAC6 expression and renal cell carcinoma
(RCC) patients. METHODS: A total of 45 fresh RCC samples and 132 paraffin embedded
tissues as well as their corresponding adjacent non-tumor tissues were
collected by surgical excision. The qRT-PCR, western blotting analysis and
immunohistochemically analysis were performed to detect the expression of
HDAC6. Kaplan-Meier curves analysis and Cox proportional hazards model
were used to analysis patients survivals as well as to adjust
stratification factors. RESULTS: The experimental results demonstrated that HDAC6 mRNA
expression level was significantly upregulated in RCC tissues compared with
adjacent non-tumor tissues, and its expression was correlated with
histologic grade and poor overall survival of RCC patients. RCC patients
with higher HDAC6 expression showed relative poor survival. Moreover, both
HDAC6 expression and histologic grade were correlated with RCC prognosis, and
high HDAC6 expression was an independent, poor prognostic factor in patient
with RCC. CONCLUSION: These analyses showed that high HDAC6 expression
was an independent, poor prognostic factor in patients with RCC, and HDAC6
could serve as a biomarker of RCCs prognostic and an indicator for RCC
progression.
