Affiliations: [a] Center for Disease Control and Prevention of Xiaoshan, Hangzhou, Zhejiang, China | [b] Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China
Correspondence:
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Corresponding author: Kun Chen, Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, China. Tel.: +86 571 88208190; Fax: +86 571 88208194; E-mail: [email protected].
Abstract: Background:Accumulated studies have suggested that single nucleotide polymorphisms (SNPs) in microRNAs are associated with risk of colorectal cancer (CRC). Objective:We tested our hypothesis that rs11014002 in hsa-miR-603 may be associated with CRC risk with a crosstalk of life-related factors. Methods:We conducted a case-control study which included 102 CRC patients and 204 matched cancer-free controls in Xiaoshan County. Results:We observed that subjects with rs11014002 CT/TT genotype had an increased susceptibility for CRC (CT vs. CC: odds ratio (OR)=2.352, 95% confidence interval (CI): 1.142–4.840, P=0.020; CT+TT vs. CC: OR=2.031, 95% CI: 1.063–3.883, P=0.032). After stratification by lifestyle-related factors, similar results were found among nonsmokers (CT vs. CC: OR=2.753, 95% CI: 1.085–6.983, P=0.033; CT+TT vs. CC: OR=2.971, 95% CI: 1.188–7.435, P=0.020) and non-alcohol drinkers (CT+TT vs. CC: OR=3.279, 95% CI: 1.071–10.033, P=0.037). Conclusions:Our data suggest that hsa-miR-603 may be involved in colorectal tumorigenesis, and the genetic polymorphism in hsa-miR-603 is associated with CRC susceptibility.
