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Positive association between vascular endothelial growth factor (VEGF) -2578 C/A variant and prostate cancer

Article type: Research Article

Authors: Martinez-Fierro, M.L.a; * | Garza-Veloz, I.a | Rojas-Martinez, A.b; c | Ortiz-Lopez, R.b; c | Castruita-de la Rosa, C.a | Ortiz-Castro, Y.a | Lazalde-Ramos, B.P.a | Cervantes-Villagrana, A.R.d | Castañeda-Lopez, M.E.a | Gomez-Guerra, L.e | Delgado-Enciso, I.f | Martinez-Torres, A.A.a

Affiliations: [a] Laboratorio de Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas, México | [b] Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, México | [c] Centro de Investigación y Desarrollo en Ciencias de la Salud, Universidad Autónoma de Nuevo León, Monterrey, México | [d] Unidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas, Zacatecas, México | [e] Servicio de Urología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, México | [f] Escuela de Medicina, Universidad de Colima, Colima, México

Correspondence: [*] Corresponding author: M.L. Martinez-Fierro, Laboratorio de Medicina Molecular, Unidad Académica de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P. 98160, Zacatecas, Zac. México. Tel.: +52 492 925 6690 Ext. 4511; E-mail: [email protected].

Keywords: Prostate cancer, VEGF, polymorphism, genetic susceptibility

DOI: 10.3233/CBM-130348

Journal: Cancer Biomarkers, vol. 13, no. 4, pp. 235-241, 2013

Published: 31 October 2013
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Abstract

Background:

Vascular endothelial growth factor (VEGF) gene is an important angiogenesis regulator related to cancer development and progression. We evaluated the association between -2578 C/A (rs699947) VEGF polymorphism and PCa in Mexican subjects, to contribute to knowledge of VEGF role in genetic epidemiology of prostate cancer (PCa).

Objective:

The aim of this study was to evaluate the association between -2578 C/A VEGF variant and PCa in Mexican population.

Methods:

A total of 249 men (77 PCa cases and 172 controls) from the Northwestern region of Mexico were screened for the -2578 C/A VEGF variant. The polymorphism was determined by polymerase chain reaction-based restriction analysis.

Results:

Genotype frequencies for C/C, C/A, and A/A, were 0.48, 0.49, 0.03 for cases and 0.41, 0.45, 0.14 for controls respectively. Genotype A/A of -2578 VEGF variant reduces the risk of PCa in an 84% among studied population (Odds Ratio 0.16; 95% CI: 0.04–0.71, P=0.007). C/C carriers showed an increased PCa risk of 6.1 times among the study population.

Conclusions:

Inheritance of -2578 A/A genotype of VEGF gene may modify PCa susceptibility risk in Mexican population.

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