Affiliations: [a] Medical Oncology Clinic, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey | [b] Department of Pathology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey | [c] Internal Medicine, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey | [d] Department of Social Work, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey
Correspondence:
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Corresponding author: Ahmet Dirican, Medical Oncology Clinic, Izmir Katip Celebi University, Ataturk Training and Research Hospital, 35360 Izmir, Turkey. Tel.: +90 232 243 43 43; E-mail: [email protected].
Abstract: Background:It is well known that tumor-infiltrating lymphocytes (TIL) and, to a lesser extent, peripheral hematologic parameters from patients with cancer have to effect on prognosis. The aim of this study was to evaluate the effect of hematologic parameters and TIL on prognosis of patients with gastric cancer. Methods:236 patients who had diagnosed as gastric adenocarcinoma. All hematologic parameters were noted at the time of diagnosis. The number of lymphocyte aggregates as well as the number of lymphocytes within these agregat was counted.The prognostic significance and correlations of high neutrophil-lymphocyte ratio (NLR) together with TIL, was evaluated by multivaried analysis. Results:The cut-off values of NLR and derived NLR (dNLR) were 3.8 and 2. The NLR was independently associated with survival (P< 0.001). dNLR was not independently associated with overall survival. No significant advantages for overall survival were found for the high TIL (p: 0.372). It was not determined correlation between TIL – NLR and TIL-lymphoid aggregate density (respectivly, P: 0.104; P: 0.246). Conclusions:The results suggest that the elevated NLR predicts poor overall survival following at the time diagnosis for all stage gastric cancer. dNLR was not independently associated with overall survival. There is insufficient evidence to the assesment of TIL by a nonspesific method. Therefore further studies is required, to confirm our hypothesis in larger patient cohorts.
