Affiliations: [a] Department of Cardio-Thoracic Surgery, People's Hospital of Beihai, Beihai, China | [b] Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of GuangXi Medical University, NanNing, Guangxi, China
Correspondence:
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Corresponding author: Xu Feng, Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of GuangXi Medical University, NanNing 530021, Guangxi, China. E-mail: [email protected].
Abstract: Background:Results of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the adenocarcinomas of lung cancer are still debated. Objective:This meta-analysis was performed to evaluate the association between GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer. Methods:The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. Results:16 reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer. The G allele and GG genotype were not associated with the susceptibility of risk of adenocarcinomas. Furthermore, in the sensitivity analysis, the results were similar with those from the non-sensitivity analysis. Conclusions:GSTP1 G allele or GG genotype is not a biomarker to be associated with the susceptibility of adenocarcinomas of lung cancer.
