Cyclin D1 polymorphism in non-small cell lung cancer in a Portuguese population

Article type: Research Article

Authors: Catarino, R.^{a; *} | Coelho, A.^a | Nogueira, A.^a | Araújo, A.^b | Gomes, M.^a | Lopes, C.^{a; c} | Medeiros, R.^{a; c; d}

Affiliations: [a] Molecular Oncology GRP CI, Portuguese Institute of Oncology, Porto, Portugal | [b] Medical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal | [c] ICBAS, Abel Salazar Institute for the Biomedical Sciences, Porto, Portugal | [d] LPCC, Research Department-Portuguese League Against Cancer (NRNorte), Porto, Portugal

Correspondence: [*] Corresponding author: Raquel Catarino, Instituto Português de Oncologia, Porto, Laboratórios – Piso 4, Unit of Molecular Oncology, R. Dr. Ant. Bernardino Almeida, 4200-072 Porto, Portugal. Tel.: +351 22 5084000 (Ext 5414); E-mail: [email protected].

Abstract: Cyclin D1 (CCND1) is a key regulatory protein of the cell cycle. The purpose of our study was to assess the role of CCND1 genetic variants influencing the genetic susceptibility of non-small cell lung cancer (NSCLC). We conducted a study of 1234 individuals, including 892 controls and 342 cases. Individuals carrying two G-alleles have a 2-fold increased risk for the development of NSCLC and the waiting time for onset of NSCLC in these patients was 2 years earlier in comparison with other individuals. Our results may be important in contributing to the knowledge of the mechanisms involved in lung carcinogenesis.

Keywords: Cyclin D1, genetic polymorphism, NSCLC

DOI: 10.3233/CBM-130294

Journal: Cancer Biomarkers, vol. 12, no. 2, pp. 65-72, 2013