Affiliations: [a] Medical Laboratory Program, Karadeniz Technical University, Vocational School of Health Sciences, Trabzon, Turkey | [b] Department of Medical Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey | [c] Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey | [d] Department of Hematology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
Correspondence:
[*]
Corresponding author: Ahmet Mentese, Medical Laboratory Program, Karadeniz Technical University, Vocational School of Health Sciences, Trabzon, Turkey. Tel.: +90 4623777876; Fax: +90 4623775344; E-mail: [email protected].
Abstract: Purposes:This study was intended to determine the diagnostic significance of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE 1) levels in gastric cancer. Methods:This retrospective study was conducted with patients with gastric cancer. SCUBE 1 titers of plasma in patients with gastric cancer were determined using an enzyme-linked immunosorbent assay (ELISA). Results:SCUBE 1 titers of gastric cancer patients were significantly higher compared with the control group (P=0.0001). At a SCUBE 1 cut-off point of 43 ng/mL, sensitivity was 67%, specificity 91%, positive predictive values (PPV) 92% and negative predictive values(NPV) 63%. SCUBE 1 levels of patients with methastase were not different from patients without methastase (P> 0.05). Dicussions:SCUBE 1 levels in patients with gastric cancer were found higher compared to healthy subjects.
