Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Shimwell, Neil J.a; | Wei, Wenbina; | Wilson, Sueb | Wakelam, Michael J. O.c | Ismail, Tariqd | Iqbal, Tariqa | Johnson, Philip J.a | Martin, Ashleya | Ward, Douglas G.a; *
Affiliations: [a] School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK | [b] School of Health & Population Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK | [c] The Babraham Institute, Babraham Research Campus Cambridge, UK | [d] Department of Surgery, University Hospitals Birmingham NHS Trust, Birmingham, UK
Correspondence: [*] Corresponding author: Douglas G. Ward, School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. Tel.: +44 0 1214149528; Fax: +44 0 1214144486; E-mail: [email protected].
Note: [1] Both authors contributed equally to this work.
Abstract: Background:Patients with colorectal cancer often present with advanced disease and concomitant poor prognosis. The best known serum biomarker, carcinoembryonic antigen (CEA) is not recommended for screening because of its limited specificity and sensitivity. A number of other circulating proteins have been suggested to be diagnostically useful but individually none of these has proved to be of sufficient sensitivity or specificity to establish a role in routine clinical practice. Here, we test the hypothesis that combining several of these biomarkers will improve diagnostic efficacy. Methods:To select the markers for our model we screened CEA and 26 other candidate biomarkers. Four candidates were selected and their concentrations determined in the serum of 239 patients (106 colorectal cancer patients and 133 non-cancer subjects). Results:Class prediction models based on CEA, DR-70 and sCD26 produced a modest increase in detection accuracy over CEA alone, particularly for early stage cancers. The sensitivity and specificity required for a clinically useful test was not reached. Conclusion:It is unlikely that a biomarker panel comprised of the currently available serum markers will generate a clinically useful diagnostic test for colorectal cancer. Our findings reiterate the urgent need to discover novel biomarkers for the detection of colorectal cancer.
DOI: 10.3233/CBM-2010-0155
Journal: Cancer Biomarkers, vol. 7, no. 3, pp. 123-132, 2010
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]