Affiliations: [a] Department of Pathology, Faculdade de Medicina da Universidade de São
Paulo, São Paulo, Brazil | [b] Pathology Laboratory, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, Brazil | [c] Laboratory of Medical Investigation (LIM 14), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil | [d] Consultoria em Patologia, Botucatu, São Paulo, Brazil
Correspondence:
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Corresponding author: Department of Pathology, Fernando N. Aguiar, Faculdade de Medicina da Universidade de São Paulo, Av Dr. Arnaldo 455, São Paulo, ZIP Code 01246-903, Brazil. Tel.: +55 011 30612981; E-mail:[email protected],[email protected]
Abstract:
BACKGROUND: Ductal carcinoma in situ is the last step preceding
invasive ductal carcinoma in breast carcinogenesis. OBJECTIVE: We investigated the role of myoepithelial cells and
epithelium characteristics as predictors of the risk of stromal invasion. METHODS: We selected 236 cases with initial diagnosis of DCIS followed
by surgical ressection distributed in groups 1 (without invasion) and 2 (with
invasive carcinoma). RESULTS: The risk of stromal invasion after a DCIS diagnosis in
biopsy was associated to triple-negative profile and loss of CD10 expression
by myoepithelial cells, and inversely associated with CK5/6 expression by
neoplastic cells and high expression of Smooth Muscle Myosin Heavy Chain
(SMMHC) by myoepithelial cells. CONCLUSIONS: A combination of characteristics of epithelial and
myoepithelial cells in DCIS in biopsy specimens is related to the risk
of stromal invasion.
