The new potential application for Mg(II) cysteinedithiocarbamate complex with anticancer activity

Article type: Research Article

Authors: Raya, Indah^a; | Kartina, Desy^{b; c} | Irfandi, Rizal^d | Sufiandi, Sandi^e | Wijaya, Ronald Ivan^c | Prihantono, Prihantono^f | Abdalrazaq, Eid A.^g | Kandeel, Mahmoud^h | Usman, Andi Nilawatiⁱ

Affiliations: [a] Department of Chemistry, Faculty of Mathematics, and Natural Science, Hasanuddin University, Makassar, Indonesia | [b] Eijkman Research Center for Molecular Biology, Health Research Organization, BRIN, Jakarta, Indonesia | [c] Department of Chemistry, Faculty of Mathematics, and Natural Science, Universitas Pakuan Bogor, Jawa Barat, Indonesia | [d] Department of Biology Education, Faculty of Teacher Training and Education, Universitas Puangrimaggalatung, Sengkang, Indonesia | [e] Directorate of Laboratory Management, Research Facilities, and Science and Technology Park, Deputy for Research and Innovation Infrastructure - The National Research and Innovation Agency of The Republic of Indonesia, Jakarta, Indonesia | [f] Department of Surgery, Faculty of Medical, Hasanuddin University, Makassar, Indonesia | [g] Department of Chemistry, Faculty of Science, Al Hussein Bin Talal University, Ma’an, Jordan | [h] Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia | [i] Midwifery Study Program, Hasanuddin University, Makassar, Indonesia

Correspondence: [*] Corresponding author: Indah Raya, Department of Chemistry, Faculty of Mathematics, and Natural Science, Hasanuddin University, Makassar, Indonesia. Tel.: +6289695544909; E-mail: [email protected]

Abstract: OBJECTIVE:The new Mg(II) cysteindithiocarbamate complex drug has been synthesized by the in-situ method and tested for its anticancer activity in vitro. METHOD:Mg(II) cysteindithiocarbamate complexes were characterized using Ultra Violet Visible, Infra-Red, melting points, and molar conductivity. RESULTS:The UV-Vis data of cysteindithiocarbamate Mg(II), shows that at 296 nm and 385 nm was occurred the electronic transitions π → π* and n → π* for CS2 and N =C =S. Whereas the IR data at wavelengths in the 393–540 cm−1 shows that there has coordinated between Mg(II) with Sulfur (S), Nitrogen (N), and Oxygen (O) atoms from cysteinedithiocarbamate ligands. CONCLUSION:The cytotoxicity test results showed that the Mg complex’s cytotoxicity was higher than that of the cytotoxicity of the Mg metal without ligands, which means that the Mg complex can be developed as a potential new anticancer drug.

Keywords: Complex Mg(II), anticancer, breast disease, cytotoxicity

DOI: 10.3233/BD-239006

Journal: Breast Disease, vol. 42, no. 1, pp. 177-182, 2023