Comparison of tumor size, histopathological grade, and molecular subtype of breast cancer at a single center study

Article type: Research Article

Authors: Awaluddin, Awaluddin^a | Pieter Jr., John^b; | Sampepajung, Elridho^b | Syamsu, Salman Ardi^b | Smaradhania, Nilam^b | Hamid, Firdaus^c | Prihantono, Prihantono^a | Laidding, Sachraswaty R.^a | Kusuma, Muhammad Ihwan^a | Faruk, Muhammad^a

Affiliations: [a] Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia | [b] Division of Oncology, Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia | [c] Department of Public Health and Community Medicine Science, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia

Correspondence: [*] Corresponding author: John Pieter Jr., Division of Oncology, Department of Surgery, Faculty of Medicine, Hasanuddin University, Jalan Perintis Kemerdekaan KM 11, Makassar, South Sulawesi, 90245, Indonesia. Fax: +62411585984; E-mail: [email protected]. ORCIDs: https://orcid.org/0000-0003-1031-0822 (ES); https://orcid.org/0000-0002-7162-8845 (SAS); https://orcid.org/0000-0003-1788-0836 (FH); https://orcid.org/0000-0002-8247-0457 (P); https://orcid.org/0000-0002-4303-971X (SRL);https://orcid.org/0000-0002-5414-1859 (MIK); https://orcid.org/0000-0002-7079-4585 (MF)

Abstract: BACKGROUND:Breast cancer (BC) is the second most frequent cancer-related death among women worldwide. Factors influencing BC patients’ survival include histopathological grade, histopathological type, stage, hormonal receptors, and number of mitotic images. OBJECTIVE:To compare the tumor size, histopathological grade, and molecular type of BC patients. METHODS:This was an observational analytic retrospective study. The population was BC patients at Dr. Wahidin Sudirohusodo Hospital from 2017 to 2021. The Kruskal–Wallis test was used to compare statistically between tumor size, histopathological grade, and molecular subtype. Significance was set at p < 0.05. RESULTS:The study included 784 patients. Most were aged 50–59 years (34.8%), with tumor size 4c (37.0%) and moderate grade (66.1%), and the most common molecular subtype was luminal A (34.2%). Bivariate analysis using the Kruskal–Wallis test found no significant difference in molecular subtypes based on tumor size (p = 0.079), but significant differences existed in molecular subtype by histopathological grade (p = 0.005) and tumor size by histopathological grade (p < 0.001). CONCLUSIONS:Significant differences existed between histopathological grade by tumor size and molecular subtype. Early diagnosis and prompt treatment of BC patients are important to prevent morbidity and mortality.

Keywords: Breast cancer, tumor size, molecular subtype, histopathological grade

DOI: 10.3233/BD-239000

Journal: Breast Disease, vol. 42, no. 1, pp. 191-195, 2023