Breast amyloidosis associated with Sjögren syndrome: A diagnostic pitfall in breast pathology

Article type: Case Report

Authors: Khaldi, Oumeima^{a; b;} | Ghalleb, Montassar^{a; b} | Jallali, Amani^{a; b} | Fenniche, Insaf^{b; c} | Somai, Mehdi^{b; c} | Daoud, Fatma^{b; c} | Boussema, Fatma^{b; c} | Kammoun, Salma^{b; d} | Hamza, Khadija^{b; d} | Ayadi, Med Ali^{a; b} | Dhieb, Tarek^{a; b}

Affiliations: [a] Surgical Oncology Department, Institute Salah Azaiez, Tunis, Tunisia | [b] Faculty of Medicine Tunis El Manar, Tunis, Tunisia | [c] Internal Medicine Department, Habib Thameur Hospital, Tunis, Tunisia | [d] Pathology Department, Institute Salah Azaiez, Tunis, Tunisia

Correspondence: [*] Corresponding author: Oumeima Khaldi, Surgical Oncology Department, Institute Salah Azaiez, Tunis, Tunisia. E-mail: [email protected]

Abstract: BACKGROUND:Amyloidosis is an uncommon disorder characterized by the extracellular deposition of amorphous and insoluble proteins in an abnormal fibrillary configuration. Mammary amyloidosis is an unusual and easily overlooked diagnosis with an ambivalent presentation that could mimic breast cancer. CASE REPORT:We here report the case of 60-year-old Caucasian woman who presented to our surgical oncology department for clinically and radiologically suspicious breast mass. A fine needle biopsy was irrelevant, so we performed a lumpectomy. Final histology revealed an amyloid deposit and further workup was consistent with nodular cutaneous and breast AL amyloidosis associated with Sjögren’s syndrome. CONCLUSION:Although rare, an awareness of the clinicopathologic characteristics of this easily overlooked entity is of great importance for breast surgeons.

Keywords: Breast amyloidosis, cutaneous amyloidosis, Sjögren syndrome, breast cancer

DOI: 10.3233/BD-230006

Journal: Breast Disease, vol. 42, no. 1, pp. 401-405, 2023