The expression of programmed death-ligand 1 and its association with histopathological grade, stage of disease, and occurrence of metastasis in breast cancer

Issue title: Second International Conference on Women and Societal Perspective on Quality of Life (WOSQUAL-2020)

Guest editors: Andi Nilawati Usman

Article type: Research Article

Authors: Pranoto, Agung Sindu^a | Haryasena, Haryasena^a | Prihantono, Prihantono^b; | Rahman, Septiman^a | Sampepajung, Daniel^a | Indra, Indra^a | Syamsu, Salman Ardy^a | Sampepajung, Elridho^a | Nelwan, Berti Julian^c | Faruk, Muhammad^b

Affiliations: [a] Division of Oncology, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia | [b] Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia | [c] Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Correspondence: [*] Corresponding author: Prihantono Prihantono, Department of Surgery, Hasanuddin University, Makassar, Indonesia. E-mail: [email protected]

Abstract: INTRODUCTION:Programmed death ligand 1 (PD-L1) plays a role in tumor escape and progression by inactivating T lymphocytes. The aim of the study reported here was to determine the relationship between the expression of PD-L1 and histopathological grade, stage of disease, and the occurrence of metastasis in breast cancer. METHODS:The observational cross-sectional study involved analyzing the expression of PD-L1 by immunohistochemistry. RESULTS:PD-LI was expressed in 43 of 60 patients with breast cancer (71.6%), mostly with a moderate histopathological grade (58.3%) and at an advanced stage (50%). Associations between the expression of PD-L1 and histopathological grade (p = 0.011), stage of disease (p = 0.009), and the occurrence of metastasis (p = 0.01) were significant, with an odds ratio of 5. CONCLUSION:The associations between the expression of PD-L1 and histopathological grade, disease stage, and occurrence of metastasis were all significant in cases of breast cancer in the sample. Those findings suggest that the expression of PD-L1 increases the progression of breast cancer.

Keywords: Programmed death ligand-one, breast cancer, immunohistochemistry, histopathological results, grading, metastasis

DOI: 10.3233/BD-219010

Journal: Breast Disease, vol. 40, no. s1, pp. S71-S76, 2021