Preoperative evaluation of breast cancer: Contrast-enhanced mammography versus contrast-enhanced magnetic resonance imaging: A systematic review and meta-analysis

Article type: Systematic Review

Authors: Shahraki, Zahra^a | Ghaffari, Mehrangiz^b | Nakhaie Moghadam, Maryam^a | Parooie, Fateme^c | Salarzaei, Morteza^c;

Affiliations: [a] Department of Obstetrics and Gynecology, Zabol University of Medical Science, Zabol, Iran | [b] Department of Pathology, Zabol University of Medical Science, Zabol, Iran | [c] Zabol University of Medical Sciences, Zabol, Iran

Correspondence: [*] Corresponding author: Morteza Salarzaei, MD, Zabol University of Medical Sciences, Zabol, Iran. E-mail: [email protected]

Abstract: INTRODUCTION:Breast cancer is the most common cancer in women worldwide. It is responsible for about 23% of cancer in females in both developed and developing countries. This study aimed to compare the diagnostic performance of contrast-enhanced mammography (CEM) and contrast-enhanced magnetic resonance imaging (CEMRI) in preoperative evaluations of breast lesions. METHODS:We searched for published literature in the English language in MEDLINE via PubMed and EMBASETM via Ovid, The Cochrane Library, and Trip database. For literature published in other languages, we searched national databases (Magiran and SID), KoreaMed, and LILACS. Metadisc1.4 software was used for statistical analysis RESULTS:A total of 1225 patients were included. The pooled sensitivity of CEM and CEMRI was 0.946 (95% CI, 0.931–0.958) and 0.935 (95% CI, 0.920–0.949), respectively. The pooled specificity of CEM and CEMRI was 0.783 (95% CI, 0.758–0.807) and 0.715 (95% CI, 0.688–0.741), respectively. The sensitivity of CEM was the most in the United States (97%) and the specificity of CEM was the most in Brazil (88%). MRI sensitivity was the most in USA and Egypt (99%) and China had the most MRI specificity (81%) in diagnosis of breast lesions. CONCLUSION:Contrast-enhanced mammography, a combination of high energy image and low energy image, can well display breast lesions and has the diagnostic efficacy equivalent to MRI. Importantly, CEM imaging shows higher specificity, positive predictive value, and diagnostic conformance rate than MRI. Despite some drawbacks such as higher irradiation and iodine usage, CEM has such advantages as convenient and fast examination, strong applicability, and low costs; thus, it can be popularized as a useful tool in breast disease.

Keywords: Contrast enhanced mammography, contrast enhanced magnetic resonance imaging, breast cancer, CEM, CEMRI

DOI: 10.3233/BD-210034

Journal: Breast Disease, vol. 41, no. 1, pp. 303-315, 2022