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Article type: Research Article
Authors: Amos, Barrya; * | Chetlen, Alisona | Williams, Nicoleb
Affiliations: [a] Department of Radiology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA | [b] Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA
Correspondence: [*] Corresponding author: Barry Amos, Department of Radiology, Penn State Milton S Hershey Medical Center, Mail Code H066, P.O. Box 850, 500 University Drive, Hershey, PA 17033, USA. Tel.: +1 717 531 1495; Fax: +1 717 531 0922; E-mail: [email protected]
Abstract: BACKGROUND:Atypical lobular hyperplasia and classic-type lobular carcinoma in situ, collectively known as lobular neoplasia, are classically described as incidental findings found on breast core-needle biopsy without distinguishing imaging characteristics. OBJECTIVE:The purpose of this study was to investigate concordant imaging findings of lobular neoplasia identified at core-needle biopsy after careful radiologic–pathologic correlation. METHODS:The pathology database was searched from October 1, 2006 to October 1, 2013 for breast biopsies yielding lobular neoplasia not associated with a coexistent malignancy or other high risk lesion in the biopsy specimen. RESULTS:Of the 482 biopsies performed containing lobular neoplasia, 65 cases had lobular neoplasia as the highest risk lesion at core-needle biopsy. Of the 65 total cases in which lobular neoplasia was the highest risk lesion, 18 (28%) cases had concordant imaging correlates. 13 of 18 (72%) cases presented as calcifications on mammography and 5 of 18 (28%) presented on magnetic resonance imaging as a focus (n = 2) or non-mass enhancement (n = 3). CONCLUSION:With careful radiologic–pathologic correlation, mammographically detected calcifications and foci or non-mass enhancement on magnetic resonance imaging can be considered concordant imaging findings of lobular neoplasia after breast core-needle biopsy.
Keywords: Lobular neoplasia, lobular carcinoma in situ, atypical lobular hyperplasia, core-needle biopsy, radiologic–pathologic concordance
DOI: 10.3233/BD-150194
Journal: Breast Disease, vol. 36, no. 1, pp. 5-14, 2016
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