Affiliations: [a] Gynecologic Oncology Section, Department of Obstetrics and Gynecology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile | [b] Genetics Branch, Center for Cancer Research, National Cancer Institute; National Institutes of Health, Bethesda, MD, USA | NIH, Bethesda, MD, USA
Correspondence:
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Corresponding author: Mauricio A. Cuello, MD. Gynecologic Oncology Section, Department of Obstetrics and Gynecology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Tel.: +562 686 3073; Fax: +562 633 1457; E-mail: [email protected]
Abstract: Dysregulation of apoptosis plays a major role in cancer etiology. Cancer cells often contain genetic abnormalities which allow the cells to survive under conditions that normally would trigger their demise. The identification of these mutations has changed the models of cancer progression from a disease of excessive proliferation to one of unbalanced cell death and cell growth. During the last decade, fundamental knowledge delineating the molecular mechanisms of apoptosis has emerged and now can be exploited to identify novel apoptotic modulators for the treatment of cancer.
DOI: 10.3233/BD-2002-15108
Journal: Breast Disease, vol. 15, no. 1, pp. 71-82, 2002
