Neuroleptic malignant syndrome: Diagnostic and therapeutic dilemmas

Article type: Research Article

Authors: Fekadu, Abebaw | Bisson, Jonathan I.

Affiliations: St Ann's Hospital, Poole, UK | University of Wales College of Medicine, Cardiff, UK

Note: [] Corresponding author. E-mail: [email protected]

Abstract: Neuroleptic malignant syndrome (NMS) is a life threatening medical state complicating the use of antipsychotic medications and other drugs that affect the dopaminergic system on administration or withdrawal. The condition was recognised nearly half a century ago, shortly after the discovery of antipsychotic medications. However, there are still no systematic studies about NMS. There are no definitive guidelines on its treatment. Although early recognition is emphasised and usually possible, delayed diagnosis is not rare. We here report on a case of NMS complicated by renal failure, and possibly respiratory failure. The report underscores the seriousness of delayed diagnosis and puts forward a comprehensive management recommendation based on our experience and the existing literature.

Journal: Behavioural Neurology, vol. 16, no. 1, pp. 9-13, 2005