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The Role of Natural Killer (NK) Cells in Experimental Autoimmune Encephalomyelitis (EAE) and Multiple Sclerosis (MS)

Article type: Research Article

Authors: Xu, Wen | Tabira, Takeshi

Affiliations: Department of Immunology, Harbin Medical University, Harbin, People's Republic of China | Department of Diagnosis, Prevention and Treatment of Dementia, Juntendo University, Hongo, Bunkyo-ku, Tokyo, Japan

Note: [] Correspondence to: Dr. Wen Xu, Department of Immunology, Harbin Medical University, 157 BaoJian Road, NanGang District, Harbin 150086, People's Republic of China. Tel.: 86 451 86674566; E-mail: [email protected]; or Dr. Takeshi Tabira, Department of Diagnosis, Prevention and Treatment of Dementia, Juntendo University, The 2nd Yaguchi Bldg. 3F, 2-11-5 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Tel.:/Fax: 81 3 6801 8332; E-mail: [email protected]

Note: [] Correspondence to: Dr. Wen Xu, Department of Immunology, Harbin Medical University, 157 BaoJian Road, NanGang District, Harbin 150086, People's Republic of China. Tel.: 86 451 86674566; E-mail: [email protected]; or Dr. Takeshi Tabira, Department of Diagnosis, Prevention and Treatment of Dementia, Juntendo University, The 2nd Yaguchi Bldg. 3F, 2-11-5 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Tel.:/Fax: 81 3 6801 8332; E-mail: [email protected]

Keywords: Natural killer cells, experimental autoimmune encephalomyelitis, multiple sclerosis, immunoregulation

DOI: 10.3233/NIB-2011-008

Journal: Advances in Neuroimmune Biology, vol. 1, no. 1, pp. 87-94, 2011

Published: 2011
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Abstract

Although NK cells are innate lymphocytes and have long been well known for their cytotoxic actions against tumor and virus infected cells, accumulating data indicate that they play an important immunoregulatory role in the pathogenesis of autoimmune diseases, such as MS and EAE. Especially, in recent years growing body of evidence suggest that NK cells have the potential to eliminate harmful self-reactive T cells and act as modulator of adaptive immunity. Here we review the recent advances in the research of NK cells related to EAE and MS, including general properties of NK cells, NK cells and EAE, and NK cells and MS, with emphasis on the mechanism of NK cell regulatory roles in EAE and MS.

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