Affiliations: Department of Nuclear Medicine, E-DA Hospital, I-Shou
University, Kaohsiung City, Taiwan | Department of Radiology, E-DA Hospital, I-Shou
University, Kaohsiung City, Taiwan | Department of Medical Imaging and Radiological
Sciences, I-Shou University, Kaohsiung City, Taiwan
Note: [] Corresponding author: Tai-Been Chen, Department of Medical
Imaging and Radiological Sciences, I-Shou University, No. 8, Yida Rd., Jiaosu
Village, Yanchao District, Kaohsiung City 82445, Taiwan. Tel.: +886 7 615 1100
ext. 7802; Fax: +886 7 615 5150; E-mail: [email protected]
Abstract: Positron emission tomography (PET) had been utilized to image gene
therapy, estimate tumor growth, detect neural function of the brain, and
diagnose disease. However, sinogram noise always results inaccurate PET images.
The factorial design of experiment (DOE), a statistical method, was applied to
investigate, correct and estimate the fraction of scattering of 2D sinogram in
PET. The DOE was included as factors of angle views and scatter media with two
levels designed. The PET sinogram after scattering correction was then
reconstructed by filtered back projection (FBP). Both Ge-68 uniform phantom and
Jaszczak anthropomorphic torso phantom were applied to exam the performance of
presented scattering correction algorithm. The signal-to-noise ratio (SNR),
standard deviation (STD) of background, and full width at half maximum (FWHM),
and uniformity test were applied to validate the performance of presented
method. The proposed method provides a narrower FWHM, smaller STD of the
background, higher SNR and better uniformity than those of original protocols.
This method should be tested for accuracy and feasibility with
three-dimensional phantoms or real animal studies and consideration effects of
cross-talk between slices in future work.
Keywords: Factorial design of experiment, PET, scattering correction algorithm
