Affiliations: [a] Department of Kidney Transplantation and Dialysis Center, The Second People’s Hospital of Shanxi Province, Taiyuan, Shanxi, China | [b] Department of Nephrology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Correspondence:
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Corresponding authors: Shao-Hua Shi, Department of Kidney Transplantation and Dialysis Center, The Second People’s Hospital of Shanxi Province, No. 9 Kouzhuang Rest Road, Yingze District, Taiyuan, Shanxi, 030000, China. Tel.: +86 13903434416; E-mail: [email protected]. Xi Qiao, Department of Nephrology, The Second Hospital of Shanxi Medical University, No. 382 Wuyi Road, Xinghualing District, Taiyuan, Shanxi 030000, China. Tel.: +86 13934566766; E-mail: [email protected].
Note: [1] These authors contributed equally to this study.
Abstract: BACKGROUND: Diarrhea is a prevalent complication after renal transplantation. OBJECTIVE: To examine the risk factors for diarrhea after renal transplantation, evaluate their combined predictive values, and analyze the prognosis. METHODS: Clinical data of patients who underwent allogeneic renal transplantation in the Second People’s Hospital of Shanxi Province from January 2019 to March 2020 were retrospectively analyzed, cases were screened and grouped, independent risk factors for diarrhea after renal transplantation were analyzed by univariate analysis and multivariate analysis, and their predictive value was evaluated by receiver operating characteristic (ROC) curve. The survival time of recipient grafts in diarrhea and non-diarrhea groups were evaluated by Kaplan-Meier and log-rank test. RESULTS: We included 166 recipients in the study and the incidence of diarrhea was 25.9%; univariate and logistic regression multivariate analyses revealed that independent risk factors for diarrhea in recipients were that the type of renal transplant donor was DCD (donation after circulatory death), immunity induction was onducted with basiliximab + antithymocyte globulin (ATG), and ATG alone, the type of mycophenolic acid (MPA) used was mycophenolate mofetil capsules, and delayed graft function (DGF) occurred after transplantation. The ROC curve indicated that the combination of the four factors had good accuracy in predicting the occurrence of diarrhea in recipients. The graft survival rate two years after the operation in the diarrhea group was significantly lower than that in the non-diarrhea group. CONCLUSION: Diarrhea affected the two-year survival rate of the graft. The type of donor, immunity induction scheme, and the type of MPA and DGF were independent risk factors for diarrhea in recipients, and the combination of the four factors had good prognostic prediction value.
Keywords: Delayed graft function, diarrhea, mycophenolic acid, renal transplantation, type of donor
