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Article type: Short Communication
Authors: Fedorova, Tatyana D.a; * | Knudsen, Karolinea | Sommerauer, Michaelb | Svendsen, Kristina B.c | Otto, Maritc | Borghammer, Pera
Affiliations: [a] Aarhus University Hospital, Department of Nuclear Medicine and PET Centre, Aarhus, Denmark | [b] Department of Neurology, University Hospital Cologne, Cologne, Germany | [c] Aarhus University Hospital, Department of Neurology, Aarhus, Denmark
Correspondence: [*] Correspondence to: Tatyana D. Fedorova, Department of Nuclear Medicine and PET Centre, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Tel.: +45 28443588; E-mail: [email protected].
Abstract: Isolated REM sleep behaviour disorder (iRBD) is a predictive marker of prodromal Lewy body disease. iRBD prevalence in the general population is around 1%, but it remains under-diagnosed, even though symptoms are alleviated by medication. We developed a population screening strategy and identified 16 iRBD patients by conducting telephone interviews and polysomnography examinations. We compared our population-screened cohort with sleep-center referred patients and found higher MoCA scores and lower MDS-UPDRS-III scores in our patients. In conclusion, screening can be used to identify iRBD patients in a cost-effective manner with the benefit of identifying patients at a very early disease stage.
Keywords: REM sleep behavior disorder, Lewy body disease, Parkinson’s disease, screening, polysomnography
DOI: 10.3233/JPD-202020
Journal: Journal of Parkinson's Disease, vol. 10, no. 3, pp. 1249-1253, 2020
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