Mirror Image of the Amyloid-β Species in Cerebrospinal Fluid and Cerebral Amyloid in Alzheimer’s Disease

Article type: Short Communication

Authors: Catania, Marcella^a | Di Fede, Giuseppe^a | Tonoli, Elisa^b | Benussi, Luisa^b | Pasquali, Claudio^a | Giaccone, Giorgio^a | Maderna, Emanuela^a | Ghidoni, Roberta^b | Tagliavini, Fabrizio^{a; *}

Affiliations: [a] Division of Neurology 5 and Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Milan, Italy | [b] Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli, Brescia, Italy

Correspondence: [*] Correspondence to: Dr. Fabrizio Tagliavini, Division of Neurology 5–Neuropathology, IRCCS Foundation - Carlo Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy.Tel.: +39 02 2394 2384; Fax: +39 02 2394 2101; [email protected]

Abstract: Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) accumulation in brain that is paralleled by Aβ1-42 reduction in cerebrospinal fluid (CSF). We analyzed the pattern of Aβ peptides, including the N- and C-terminal truncated fragments, in brain and CSF from two familial and one sporadic AD cases. We found that (i) each patient is characterized by a distinct Aβ profile in CSF and brain deposits and (ii) the CSF Aβ pattern mirrors the Aβ profile of cerebral amyloid. These results suggest the existence of different molecular AD subtypes which can be recognized by CSF analysis, enabling patient stratification.

Keywords: Alzheimer’s disease, amyloid-β, biomarker, cerebrospinal fluid, SELDI-TOF MS

DOI: 10.3233/JAD-150179

Journal: Journal of Alzheimer's Disease, vol. 47, no. 4, pp. 877-881, 2015