Technology and Health Care - Volume 32, issue 6

Authors: Veihelmann, A. | Beck, F. | Huth, J. | Spetzger, U. | Schulze-Pellengahr, C. | Teske, W.

Article Type: Research Article

Abstract: BACKGROUND: It is estimated that a significant number of spinal surgeries are performed, but many patients do not often benefit. OBJECTIVE: Our aim was to determine how effective minimally invasive pain procedures (MIP) are in chronic low back pain (CLBP) patients with proven degenerative causes (specific low back pain). METHODS: 386 eligible patients with CLBP/sciatica resistant to conservative therapy and scheduled for open surgery were screened, and 167 could be enrolled in this study. Indications for MIP in the remaining 150 individuals were made by one experienced spinal surgeon. Before and 6 months …after the intervention, the numeric rating scale (NRS) and Oswestry Disability Index (ODI) were recorded. MIP was performed, such as radiofrequency of the facet and SI-joint, intradiscal electrothermal therapy in case of discogenic pain, as well as epidural neuroplasty in patients with disc herniation/epidural fibrosis. RESULTS: There was a statistically significant decrease in NRS (p < 0.05), as well as a significant increase in ODI (p < 0.001) 6 months after the procedures. This was also true for the results of all different pain generators and subsequent performed procedures alone. CONCLUSIONS: The indication of MIP should be routinely reviewed in patients with CLBP to avoid potentially open surgery and a burden on healthcare costs. Show more

Keywords: Minimal invasive surgical procedures, low back pain mechanical, disc herniation, sciatica, discogenic pain

DOI: 10.3233/THC-241003

Citation: Technology and Health Care, vol. 32, no. 6, pp. 4727-4741, 2024

Authors: Yao, Chunying | Ma, Qiubo | Shi, Ying | Zhang, Na | Pang, Lei

Article Type: Research Article

Abstract: BACKGROUND: Membranous nephropathy (MN), also known as membranous glomerulonephritis, is a leading cause of adult nephrotic syndrome. The main pathological features encompass the deposition of immune complexes within the glomerular basement membrane epithelial cells, thickening of the basement membrane, and fusion of the foot process. OBJECTIVE: This study aims to investigate the role of the immune and inflammatory modulator miR-223 in the immunosuppressive and anti-inflammatory effects of cyclophosphamide (CTX) on membranous nephropathy (MN). METHODS: miR-223 mimetics or inhibitors was used to regulate miR-223 levels. LPS induced inflammatory cell model and cell polarization. CTX …was used to treat Lipopolysaccharides (LPS) induced inflammatory response and polarization. Cationic bovine serum albumin (c-BSA) induced BALB/c mouse MN model, while CTX was used to treat c-BSA induced MN. RESULTS: The miR-223 level in LPS induced inflammatory model cells was lower than that in control cells. The levels of inflammatory factors in LPS+ miR-223 mimetics and CTX+ miR-223i cells were lower than those in LPS and miR-223i cells. The protein levels of LPS+ miR-223 mimic, CTX+ miR-223i macrophage M2 phenotype markers Arginase-1 (Arg1), transforming growth factor β 1 (TGF-β 1), anti-inflammatory factors interleukin-4 (IL4) and interleukin-13 (IL13) were significantly higher than those of LPS and miR-223i. The effect of CTX was confirmed in a BALB/c mouse MN model induced by cationic bovine serum albumin (c-BSA). CONCLUSION: CTX upregulates the expression of miR-223, promotes polarization of M2 macrophages, alleviates the inflammatory response and renal injury of MN. Show more

Keywords: Cyclophosphamide, membranous nephropathy, macrophage, miR-223, inflammatory response

DOI: 10.3233/THC-241175

Citation: Technology and Health Care, vol. 32, no. 6, pp. 4743-4756, 2024

Article Type: Other

Citation: Technology and Health Care, vol. 32, no. 6, pp. 4757-4757, 2024

Authors: Lin, Chi | Yu, Chang Wu | Wang, Ning

Article Type: Editorial

DOI: 10.3233/THC-248052

Citation: Technology and Health Care, vol. 32, no. 6, pp. 4759-4764, 2024

Authors: S.S., Akilan | Devprasad, Kayathri Devi | J, Raja Sekar

Article Type: Research Article

Abstract: BACKGROUND: Wireless Body Area Networks (WBANs) are integral to modern healthcare systems, providing continuous health monitoring and real-time data transmission. The sensitivity of medical data being transmitted makes security a significant concern in WBANs. OBJECTIVE: This study explores the application of the Elliptic Curve Cryptography (ECC)-based Diffie-Hellman Key Exchange (ECDH) algorithm to enhance security within WBANs. METHOD: The study investigates the suitability of ECC for this context and evaluates the performance and security implications of implementing ECDH in WBANs. RESULTS: The findings reveal that ECDH provides a robust and computationally …efficient solution for secure key exchange in WBANs, addressing inherent vulnerabilities. CONCLUSION: The adoption of ECC-based ECDH is poised to bolster data confidentiality and integrity in WBANs, promoting trust and widespread use of these networks in healthcare applications. This research contributes to the growing body of knowledge regarding security measures in WBANs and opens new avenues for the secure transmission of sensitive medical information. Show more

Keywords: Wireless Body Area Networks (WBANs), security, Elliptic Curve Cryptography (ECC), Diffie-Hellman key exchange (DHE), ECDH

DOI: 10.3233/THC-231614

Citation: Technology and Health Care, vol. 32, no. 6, pp. 4765-4784, 2024

Authors: Wu, Weihua | Chen, Jie | An, Peng | Feng, Yangmei | Li, Chen | Zhang, Meiqi | Yu, Zhenfei

Article Type: Research Article

Abstract: BACKGROUND: The kidney is the most vulnerable organ in severe patients. In severe cases, the fatality rate of acute kidney damage is as high as 30% ∼ 60%. Severe ultrasound is a non-invasive method to evaluate renal blood flow. It can give a semi-quantitative score of renal blood flow and measure the Resistance Index (RI), which can reflect renal artery blood flow to a certain extent. OBJECTIVE: There is little literature on hemodynamic regulation in septic shock patients, but almost no research report on the relationship between hemodynamics and RI exists. Therefore, this …paper proposed the analysis of severe ultrasound and gene diagnosis in cardiac index and peripheral vascular RI of shock patients. METHODS: This paper mainly expounded on detecting renal function parameters and RI in patients with viral shock to understand further the correlation between them and renal flow and RI. RESULTS: It could be seen from the experimental results that the P values before and after resuscitation in the two groups with and without elevated Cardiac Output (CO) were 0.41 and 0.12, respectively, which were more significant than 0.05. CONCLUSION: RI had no apparent relationship with CO, and RI could not be used as an evaluation index for patients with early septic shock. Show more

Keywords: Severe ultrasound, shock patients, gene diagnosis, genetic algorithm

DOI: 10.3233/THC-231859

Citation: Technology and Health Care, vol. 32, no. 6, pp. 4785-4800, 2024

Authors: Yu, Limei | Wang, Yuxia | Chen, Yun | Wang, Yakun | Zhang, Haida | Zhang, Meiqi | Li, Chen

Article Type: Research Article

Abstract: BACKGROUND: The incidence of brain injury is increasing year by year, and it has become one of the major diseases threatening human life in today’s society. From the perspective of the causes of brain injury, it is mainly due to falls from high places, traffic accidents, etc. Severe brain injury patients often lose consciousness. In recent years, the emergence of integrated traditional Chinese and Western medicine has provided a new approach and new ideas for the treatment of craniocerebral trauma. OBJECTIVE: The article systematically and scientifically expounded the role of Xingnaojing injection in the treatment of …brain injury by comparing the GCS (Glasgow Coma Scale) score, changes in intracranial pressure, the incidence of complications after brain injury, the transformation from moderate brain injury to severe brain injury, and recovery of consciousness. METHODS: For the problem of gene polymorphism in patients with brain injury, this article discussed the role of APOE2 (Apolipoprotein E2), ε 3, ε 4 in brain injury. All patients had a clear history of trauma and received strict nervous system examination and CT scanning when they were admitted to the hospital. After craniocerebral trauma surgery or conservative therapy, patients should take a Xingnaojing injection of 30 ml and a 0.9% sodium chloride injection of 250 ml after admission. After the operation, respiratory tract nursing should be strengthened, and patients who cannot eat should be given nasal feeding, acupuncture, and physiotherapy to prevent bedridden complications. RESULTS: The probability of epilepsy after brain injury was 27%. CONCLUSION: The article would help to evaluate the degree of brain damage and prognosis of patients. Show more

Keywords: Xingnaojing injection, craniocerebral injury, gene polymorphism, quantitative evaluation

DOI: 10.3233/THC-231864

Citation: Technology and Health Care, vol. 32, no. 6, pp. 4801-4818, 2024

Authors: Li, Jun | Li, Rong

Article Type: Research Article

Abstract: BACKGROUND: Double rocking jump rope training can effectively enhance physical recovery, adaptability to exercise load, and lower limb muscle strength of badminton players in sports colleges, thus offering valuable insights for improving training methods in sports colleges and universities. OBJECTIVE: To investigate the effect of double rocking jump rope training on the lower limb muscle strength of badminton players specializing in badminton in sports colleges. METHODS: An experimental study was conducted through a ten-week teaching intervention experiment with badminton players. Relevant heart rate indexes and badminton related lower limb muscle strength indexes were …measured before and after the experiment. The data of the measured relevant indexes were statistically and analytically analyzed. At the end of the experiment, the physical recovery level and the heart’s adaptability to the exercise load of the control group were improved, and the lower limb muscle strength test indexes and sports performance were better than before the experiment. In the experimental group, badminton players’ physical function, anaerobic metabolism of the body and other aspects also improved. RESULTS: The physical function of the experimental group of badminton players, the energy supply capacity of the body anaerobic metabolism and aerobic work capacity all have an enhancement effect, enabling badminton players to adapt to large exercise loads quickly and improve the recovery rate of physical fitness. CONCLUSION: The introduction of double rocking jump rope into badminton training classes in sports colleges and universities as a means of lower limb muscle strength training is conducive to improving the level of lower limb muscle strength of special badminton players, enriching the teaching and training means of lower limb muscle strength in sports colleges and universities, and broadening the research field of lower limb muscle strength in badminton in sports colleges and universities. Show more

Keywords: Double rocking jump rope, badminton, lower limb muscle strength, AdaBoost algorithm optimization

DOI: 10.3233/THC-231868

Citation: Technology and Health Care, vol. 32, no. 6, pp. 4819-4836, 2024

Authors: Yu, Hongxia

Article Type: Research Article

Abstract: BACKGROUND: The use of complementary therapies to relieve the side effects of chemotherapy in lung cancer patients is becoming increasingly popular. Practices from traditional Chinese medicine, such as acupoint massage and five-tone therapy, have demonstrated potential in alleviating symptoms such as nausea and vomiting experienced during chemotherapy. OBJECTIVE: This study aims to determine the effectiveness of combining five-tone therapy with acupoint massage in reducing chemotherapy-related symptoms in lung cancer patients. The main objective is to determine how these complementary therapies affect the quality of life and well-being of people undergoing chemotherapy for lung cancer. …METHODS: In this paper, 80 patients diagnosed with lung cancer who needed chemotherapy drugs were randomly divided into 2 groups, 40 patients. The first was treatment; the second was control. Chemotherapy drugs were combined with a 5-hydroxytryptamine blocker (granisetron), and acupoint massage was combined with pentatone therapy to prevent nausea, vomiting, and other gastrointestinal reactions. A 5-hydroxytryptamine blocker (granisetron) was combined with chemotherapy drugs to prevent nausea, vomiting, and other gastrointestinal reactions. Moreover, the difference in treatment effect was observed. RESULTS: Among 40 cases in treatment, 13 cases were clinically controlled, 15 cases were markedly effective, 9 cases were effective, and 3 cases were ineffective. The total effective rate was 92.50%; among 40 cases in control, 6 cases were clinically controlled, 16 cases were markedly effective, 12 cases were practical, and 6 cases were invalid. The total effective rate was 85.00%. CONCLUSION: By integrating traditional Chinese medicine techniques, healthcare professionals can augment the supportive care offered to those undergoing chemotherapy for lung cancer. Show more

Keywords: Acupoint massage, pentatonic therapy, treatment, chemotherapy drugs, vomiting

DOI: 10.3233/THC-231890

Citation: Technology and Health Care, vol. 32, no. 6, pp. 4837-4856, 2024

Authors: Li, Chenxi | Li, Jian | Lu, Yao | Hou, Jiahui | Zhi, Zhaoyu | Zhao, Baocun | Zhang, Xiumei

Article Type: Research Article

Abstract: BACKGROUND: Volumetric modulated arc therapy (VMAT) guided by ultrasound is a novel radiation therapy technique that facilitates the delineation of the tumor target area under image guidance, enhancing the precision of radiation therapy and maximizing the protection of surrounding tissues. OBJECTIVE: The objective of this paper is to investigate the effectiveness of VMAT under ultrasonic guidance for cervical cancer patients and its impact on radiotherapy dosage and prognosis. METHODS: A retrospective analysis encompassed 128 instances of cervical cancer patients who were admitted to our medical facility between April 2019 and April 2021. The …patients were categorized into an observation cohort and a control cohort, depending on variations in treatment modalities post-admission. The control group underwent conventional radiotherapy, whereas the observation group received VMAT guided by ultrasound. Clinical efficacy, average radiation dosages (in the radiotherapy target area, rectum, and bladder), radiotherapy-related toxicities during treatment, and one-year survival rates were compared between the two groups. Additionally, variances in pre- and post-treatment serum levels of squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), and carbohydrate antigen 724 (CA724) were subjected to assessment. RESULTS: When compared to the control group (64.52%), the observation cohort’s comprehensive effectiveness rate was considerably greater (80.30%). The observation group saw lower average radiation exposures and a reduction in the post-treatment concentrations of CEA, SCC-Ag, and CA724. The overall incidence of adverse effects from radiation treatment also declined. The observation group had a greater one-year survival rate (90.48%) than the control group (73.33%). When comparing the observation cohort to the control group, Kaplan-Meier survival analysis showed a significantly higher one-year survival rate (Log-Rank = 6.530, P = 0.011). CONCLUSION: VMAT guided by ultrasound for patients with cervical cancer demonstrates promising short- and long-term treatment outcomes. It also leads to improvements in serum CEA, SCC-Ag, and CA724 levels, as well as reductions in the average radiation dosages to the radiotherapy target area, rectum, and bladder. This approach warrants attention from clinicians in clinical practice. Show more

Keywords: Cervical cancer, intensity-modulated radiation therapy, ultrasound, radiation dosage, prognosis

DOI: 10.3233/THC-231977

Citation: Technology and Health Care, vol. 32, no. 6, pp. 4857-4868, 2024