Mediterranean Journal of Nutrition and Metabolism - Volume 6, issue 3

Authors: Sukkar, Samir Giuseppe | Vaccaro, Alberto | Ravera, Giovanni Battista | Borrini, Claudia | Gradaschi, Raffaella | Massa Sacchi-Nemours, Anna | Cordera, Renzo | Andraghetti, Gabriella

Article Type: Short Communication

Abstract: Whey proteins represent the most satiating nutrients. In particular, their effects are due to enterohormonal changes (CCK, GLP-1 and PYY 1–36) observed after their exclusive ingestion. Glucomannan has important satiety property due to volume increase following gelification. The aim of the study is the evaluation of subjective rate of hunger and enterohormone concentrations (CCK, GLP-1, PYY 1–36) following oral loading of a mixture containing WP (8 g) or casein (8 g) plus glucomannan (1 g) (Colordiet® , Inpha DUEMILA Srl Lecco, Italy). The study was conducted as a double-blind crossover with five healthy volunteers (BMI 22–26 kg/m2 aging 18–65 …years) in acute and a wash-out period of 1 week between the first and the second evaluation. From the analysis of the data, we observe that the load with WP induces a significant decrease in the desire to eat after 90 min (P < 0.0446) when compared with casein. As far as plasma hormones are concerned, there was a significant increase only in GLP-1 at 90 min after WP (P < 0.00166) and 180 min after casein (T0 vs. T180 P = 0.000129). There is a significant correlation between the increase in GLP-1 and decrease of desire to eat (R = −0.93). There is a tendency to the increasing of CCK after 90 min, which is not significant (P = 0.091). These results could be due to (a) the low number of cases or (b) the low dose of protein used. The present study suggests that a mixture of WP plus glucomannan exerts a decrease in the desire to eat which is correlated to enterohormonal modification (GLP-1 increase) despite the low content of protein (8 g) and the presence of glucomannan, which could reduce the fast absorption of WP in relation to the net forming during the gelification of the gastric environment. Show more

Keywords: Whey protein, Appetite suppressant, GI hormones, CCK, GLP-1, PYY, Obesity

DOI: 10.3233/s12349-013-0121-7

Citation: Mediterranean Journal of Nutrition and Metabolism, vol. 6, no. 3, pp. 259-266, 2013

Authors: Sukkar, Samir Giuseppe | Vaccaro, Alberto | Ravera, Giovanni Battista | Borrini, Claudia | Gradaschi, Raffaella | Massa Sacchi-Nemours, Anna | Cordera, Renzo | Andraghetti, Gabriella

Article Type: Correction

DOI: 10.3233/s12349-013-0141-3

Citation: Mediterranean Journal of Nutrition and Metabolism, vol. 6, no. 3, pp. 267-267, 2013

Authors: Maddah, Mohsen | Salari, Arsalan | Momeni, Maryam

Article Type: Short Communication

Abstract: In Iran, coronary artery disease (CAD) is the leading cause of mortality. There is less information on urban–rural difference in CAD in Iran. Between June 2010 and December 2011 a total of 288 patients (186 urban and 102 rural) with angiography-approved CAD were sequentially recruited in the main heart hospital in Rasht, northern Iran. Data on age, living areas, educational levels, blood lipids, blood glucose levels, blood pressure, body mass index, waist circumference, cigarette smoking and current drug therapy were collected. In the rural men the prevalence of hypertension, diabetes and smoking was lower than the urban men and the …prevalence of other risk factors was not different. In the rural women the prevalence of overweight/obesity and waist circumference was lower than the urban women and the distributions of other measured risk factors were the same. This study showed that Iranian urban and rural women were not behind men regarding age for developing CAD. Show more

Keywords: Coronary artery disease, Developing countries, Iran, Rural

DOI: 10.3233/s12349-013-0142-2

Citation: Mediterranean Journal of Nutrition and Metabolism, vol. 6, no. 3, pp. 269-271, 2013